Hiccups and vomiting as initial manifestations of multiple sclerosis.

R, Birkhead; Friedman, Jason

doi:10.1136/jnnp.50.2.232

Cited by 10 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 There have been six reported cases of MS with IHN in which MRI showed the medullary dorsomedial lesions extending to the cervical cord that involved more than three vertebral segments like our cases. [4][5][6][7][8] They were relatively severe myelitis, and four of six cases with CSF data showed low intrathecal IgG synthesis or no oligoclonal band. 4,6,8 These findings are commonly seen in NMO but not in classical MS.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

et al. 2005

View full text Add to dashboard Cite

Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone. In six cases, MRI detected linear medullary lesions involving the pericanal region, the area postrema, and the nucleus tractus solitarius. Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS.

show abstract

Section: Resultsmentioning

confidence: 99%

“…IHN defined as bouts lasting more than 48 hours can be caused by a variety of diseases affecting the medulla oblongata, 3 and demyelinating diseases such as multiple sclerosis (MS) are a rare etiology of IHN. [3][4][5][6][7][8] In the present study, we reviewed our cases of NMO and MS to analyze the frequency of IHN and its clinical and MRI findings.…”

mentioning

confidence: 99%

Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Intermittent bouts of hiccups with hiccup-free intervals have been reported [ 105 , 106 , 107 , 108 ]. Some constituted the presenting symptom of the disease [ 105 , 107 ], some were associated with other symptoms (e.g., syncope, vomiting, neurological symptoms) [ 106 , 107 , 108 ] as well as with cervical or brainstem lesions (e.g., ventral paramedian portion of the medulla) [ 106 , 107 , 108 ]. A malignant form of hiccups was described in association with cervico-medullary lesions leading to quadriparesis and respiratory failure within hours, but the report does not characterize the nature of hiccups (continuous vs. intermittent bouts) [ 109 ].…”

Section: Paroxysmal Symptoms Categoriesmentioning

confidence: 99%

Paroxysmal Symptoms in Multiple Sclerosis—A Review of the Literature

Freiha

Riachi

Chalah

et al. 2020

JCM

View full text Add to dashboard Cite

Paroxysmal symptoms are well-recognized manifestations of multiple sclerosis (MS). These are characterized by multiple, brief, sudden onset, and stereotyped episodes. They manifest as motor, sensory, visual, brainstem, and autonomic symptoms. When occurring in the setting of an established MS, the diagnosis is relatively straightforward. Conversely, the diagnosis is significantly more challenging when they occur as the initial manifestation of MS. The aim of this review is to summarize the various forms of paroxysmal symptoms reported in MS, with emphasis on the clinical features, radiological findings and treatment options.

show abstract

“…Although multiple sclerosis (MS) is characterized by protean manifestations, intractable hiccup (IH) is rare and has been described only in isolated case reports.'" 3 We describe a patient with clinically definite MS presenting with IH who responded well to corticosteroid therapy.…”

mentioning

confidence: 97%

Intractable Hiccup Due to Multiple Sclerosis: MR Imaging of Medullary Plaque

Chang

Wu²,

Tsai³

et al. 1994

Can. j. neurol. sci.

View full text Add to dashboard Cite

Abstract:We describe a 31-year-old man with clinically definite multiple sclerosis who presented with intractable hiccup for one month prior to admission. The responsible lesion was confirmed by magnetic resonance imaging to be a plaque in the ventral paramedian portion of the medulla oblongata.Resume: Hoquet incoercible du a une sclerose en plaques: visualisation d'une plaque medullaire par RMN. Nous decrivons le cas d'un homme de 31 ans, atteint d'une sclerose en plaques cliniquement certaine, qui a pr6sent6 un hoquet incoercible un mois avant son admission. L'imagerie par resonance magnetique a confirme' que la lesion en cause etait une plaque situee dans la portion param6diane ventrale du bulbe rachidien.Can. J. Neurol. Sci. 1994; 21: 271-272 Although multiple sclerosis (MS) is characterized by protean manifestations, intractable hiccup (IH) is rare and has been described only in isolated case reports. '" 3 We describe a patient with clinically definite MS presenting with IH who responded well to corticosteroid therapy. CASE REPORTA 31-year-old businessman experienced IH, vertigo and vomiting for two weeks in December 1987. Six weeks later, the patient developed transient episodes of double vision on left gaze and paroxysmal attacks of left facial numbness. Cranial nerve examination disclosed impaired left visual acuity, horizontal nystagmus on left gaze, hypesthesia and dysesthesia in the left face and ipsilateral neurosensory hearing impairment. Additional neurologic findings were mild paraparesis with brisk tendon reflexes, right dysmetria and symmetrical sensory disturbance below the T |0 level bilaterally.Laboratory examinations were unremarkable, except that cerebrospinal fluid (CSF) study showed a slight mononuclear pleocytosis as well as mild protein elevation with 18% IgG. Pattern-shift visualevoked potentials (EP) revealed prolonged latencies bilaterally. Studies of short-latency somatosensory EP and brainstem auditory EP were compatible with intrinsic brainstem lesions. However, a cranial computed tomographic (CT) scan was unremarkable. In the following 4 years, he had one relapse and remission of the right hemiparesis and brachial monoparesthesia.He was readmitted to our hospital in September 1992 because of IH for about one month. The patient had 10 to 15 episodes of hiccup per day and each episode lasted minutes to hours. The hiccups could not be suppressed by Valsalva maneuver, vagal stimulation, or irritation of the uvula. Therapeutic trials with metoclopramide, chlorpromazine and diphenylhydantoin were all in vain. The patient also complained of episodic vomiting, easy choking, double vision, unsteady gait and a symmetrical ascending numbness and tight sensation up to the occipital region.On neurologic examination, slow saccadic movement on right gaze was present with concomitant horizontal nystagmus. Dysarthria, bilateral trigeminal hypesthesia, cerebellar dysmetria and diminished proprioception of all extremities were also noted. There was no motor weakness, but a generalized hyperref...

show abstract

Hiccups and vomiting as initial manifestations of multiple sclerosis.

Cited by 10 publications

References 2 publications

Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica

Paroxysmal Symptoms in Multiple Sclerosis—A Review of the Literature

Intractable Hiccup Due to Multiple Sclerosis: MR Imaging of Medullary Plaque

Contact Info

Product

Resources

About