HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

Burrows, Kyle; Antignano, Frann; Chenery, Alistair; Bramhall, Michael; Kor̆ínek, Vladimír; Underhill, T. Michael; Zaph, Colby

doi:10.1371/journal.ppat.1006869

Cited by 18 publications

(15 citation statements)

References 43 publications

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“…ILC3s respond to food-induced expression of neuropeptide vasoactive intestinal peptide (VIP) allowing them to maintain epithelial barrier integrity [90]. Dietary nutrient deficiencies, such as vitamin A or vitamin D deficiency, leads to a loss of ILC3s in the gut [91][92][93], while ILC2 number and effector function are enhanced by increased FAO and acquisition of long-chain fatty acids [61]. Dietary nutrient oversupply of fat, which leads to obesity, results in the hypertrophy of adipocytes, limiting their nutrient and oxygen availability and resulting in a sustained stress response in both adipocytes and stromal cells [94][95][96].…”

Section: Environmental Changes In Host Metabolism Influence Ilc Biologymentioning

confidence: 99%

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activating signals become dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease. In this review, we summarize studies that support evidence for the ability of ILCs to influence tissue and systemic metabolism, as well as how ILCs can be regulated by environmental changes in systemic host metabolism. We also highlight studies demonstrating how ILC- intrinsic metabolism influences their activation, proliferation, and homeostasis. Finally, this review discusses the challenges and open questions in the rapidly expanding field of ILCs and immunometabolism.

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Section: Environmental Changes In Host Metabolism Influence Ilc Biologymentioning

confidence: 99%

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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“…In addition, misregulation of either Wnt or TGFβ greatly impacts Pitx2 levels, suggesting that the different pathways interact for proper signaling control 89,97. Potential crosstalk is observed in the upregulation of genes associated with RA signaling ( Sox6 and Hic1 ), which suppress Wnt signaling 119–123. The Wnt activating genes ( Prrx2 and Hmga2 ) are upregulated by TGFβ,51,52 and we observed that Hmga2 localizes to the corneal epithelium where Wnt expression is dominant 56…”

Section: Discussionmentioning

confidence: 73%

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

Lwigale

2019

Invest. Ophthalmol. Vis. Sci.

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PurposeDefects in neural crest development are a major contributing factor in corneal dysgenesis, but little is known about the genetic landscape during corneal development. The purpose of this study was to provide a detailed transcriptome profile and evaluate changes in gene expression during mouse corneal development.MethodsRNA sequencing was used to uncover the transcriptomic profile of periocular mesenchyme (pNC) isolated at embryonic day (E) 10.5 and corneas isolated at E14.5 and E16.5. The spatiotemporal expression of several differentially expressed genes was validated by in situ hybridization.ResultsAnalysis of the whole-transcriptome profile between pNC and embryonic corneas identified 3815 unique differentially expressed genes. Pathway analysis revealed an enrichment of differentially expressed genes involved in signal transduction (retinoic acid, transforming growth factor-β, and Wnt pathways) and transcriptional regulation.ConclusionsOur analyses, for the first time, identify a large number of differentially expressed genes during progressive stages of mouse corneal development. Our data provide a comprehensive transcriptomic profile of the developing cornea. Combined, these data serve as a valuable resource for the identification of novel regulatory networks crucial for the advancement of studies in congenital defects, stem cell therapy, bioengineering, and adult corneal diseases.

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“…Therefore, CD4 + cells are the main source of IL-22 in the late phase of infection [ 74 , 75 ]. Activation of ILC3 during C. rodentium infection is mediated by many pathways including specific activation of ILC3 surface receptors [ 59 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ], diet- and bacteria-derived metabolites [ 85 , 86 , 87 , 88 , 89 , 90 , 91 ] and interposed phagocytes [ 92 , 93 , 94 , 95 , 96 ].…”

Section: Infections Of the Gastrointestinal Tractmentioning

confidence: 99%

“…Recently, it has been also shown that ILCs express the transcriptional repressor, hypermethylated in cancer 1 (HIC1, ZBTB29), which is regulated by vitamin A. Lack of HIC1 abolished IL-22-expressing ILC3 and increased susceptibility to C. rodentium infection [ 88 ]. In contrast to vitamin A, vitamin D has been shown to negatively regulate ILC3 in C. rodentium infection.…”

Section: Infections Of the Gastrointestinal Tractmentioning

confidence: 99%

Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense

2020

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Innate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barrier such as the respiratory and gastrointestinal tracts. Due to their close proximity to the mucosal surface, ILCs are exposed to a variety of both commensal and pathogenic bacteria. Under non-pathological conditions, ILCs have been shown to be important regulators for the maintenance of tissue homeostasis by mutual interactions with the microbiome. Besides these important functions at homeostasis, several studies have also provided emerging evidence that ILCs contribute to defense against pathogenic bacterial infection by responding rapidly to the pathogens as well as orchestrating other immune cells. In this review, we summarize recent advances in our understanding of the interactions of ILCs and bacteria, with special focus on the function of the different ILC subsets in bacterial infections.

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HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

Cited by 18 publications

References 43 publications

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense

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