Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice

El-Shiekh, Riham A.; Ashour, Rehab M.; El-Haleim, Enas A Abd; Ahmed, Kawkab A.; Abdel‐Sattar, Essam

doi:10.1016/j.biopha.2020.110303

Cited by 49 publications

(27 citation statements)

References 49 publications

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“…We may conclude that the wheat grain with high anthocyanin content improves cognitive function; its application is safe for AD-like pathology. Together with previous reports on the positive effects of anthocyanin-enriched extracts in mouse AD models [ 21 , 60 , 61 ], the results of the study confirm the potential of the anthocyanin-enriched wheat grain as a functional food for dietary supplementation against cognitive decline from the early stages of AD progression.…”

Section: Discussionsupporting

confidence: 86%

Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders

et al. 2020

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Functional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated the effects of a grain diet rich in anthocyanins in a mouse model of Alzheimer’s disease induced by amyloid-beta (Aβ) and a transgenic mouse model of Parkinson’s disease (PD) with overexpression of human alpha-synuclein. The mice were kept at a diet that consisted of the wheat grain of near isogenic lines differing in anthocyanin content for five–six months. The anthocyanin-rich diet was safe and possessed positive effects on cognitive function. Anthocyanins prevented deficits in working memory induced by Aβ or a long-term grain mono-diet; they partially reversed episodic memory alterations. Both types of grain diets prolonged memory extinction and rescued its facilitation in the PD model. The dynamics of the extinction in the group fed with the anthocyanin-rich wheat was closer to that in a group of wild-type mice given standard chow. The anthocyanin-rich diet reduced alpha-synuclein accumulation and modulated microglial response in the brain of the transgenic mice including the elevated expression of arginase1 that marks M2 microglia. Thus, anthocyanin-rich wheat is suggested as a promising source of functional nutrition at the early stages of neurodegenerative disorders.

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Section: Discussionsupporting

confidence: 86%

Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders

et al. 2020

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“…Nevertheless, it should be also outlined that the ADME properties of this nutraceutical product, and consequently its biological effect in vivo, might be ascribed to the concurrent presence of all the PRES components. Finally, both oleuropein and hibiscus acid have shown interesting and promising neuroprotective effects also in in vivo models of neurodegenerative diseases [10,[40][41][42][43]. Moreover, oleuropein or its active metabolite, hydroxytyrosol, is found in a significant amount in the brain following oleuropein peripheral administration [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…Human SH-SY5Y neuroblastoma cells (ECACC Cat# 94030304, passages [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], grown in standard conditions, as already reported [14] were sub-cultured at 70-80% confluent, medium changed twice/week and experiments were performed by using cells in the exponential phase of growth.…”

Section: Cell Culturesmentioning

confidence: 99%

“…This formulation, the composition of which has been fully characterized [8] (see also below) possesses antioxidant and cytoprotective effects [8,9], mainly due to the phenolic compounds found in both plants which includes hydroxytyrosol, oleuropein, flavonoids, chalcones, tannins, and hibiscus acid. Most of them possess neuroprotective properties along with many other positive effects [10][11][12][13]. Therefore, the aim of the present work was to assess the neuroprotective properties of PRES toward OS-mediated injury in human neuroblastoma SH-SY5Y cells.…”

Section: Introductionmentioning

confidence: 99%

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Olive Leaves and Hibiscus Flowers Extracts-Based Preparation Protect Brain from Oxidative Stress-Induced Injury

et al. 2020

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Oxidative stress (OS) arising from tissue redox imbalance, critically contributes to the development of neurodegenerative disorders. Thus, natural compounds, owing to their antioxidant properties, have promising therapeutic potential. Pres phytum (PRES) is a nutraceutical product composed of leaves- and flowers-extracts of Olea europaea L. and Hibiscus sabdariffa L., respectively, the composition of which has been characterized by HPLC coupled to a UV-Vis and QqQ-Ms detector. As PRES possess antioxidant, antiapoptotic and anti-inflammatory properties, the aim of this study was to assess its neuroprotective effects in human neuroblastoma SH-SY5Y cells and in rat brain slices subjected to OS. PRES (1–50 µg/mL) reverted the decrease in viability as well as the increase in sub-diploid-, DAPI-and annexin V-positive-cells, reduced ROS formation, recovered the mitochondrial potential and caspase-3 and 9 activity changes caused by OS. PRES (50–100 µg/mL) neuroprotective effects occurred also in rat brain slices subjected to H2O2 challenge. Finally, as the neuroprotective potential of PRES is strictly related to its penetration into the brain and a relatively good pharmacokinetic profile, an in-silico prediction of its components drug-like properties was carried out. The present results suggest the possibility of PRES as a nutraceutical, which could help in preventing neurodegenerative diseases.

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“…In summary, Hibiscus represents a promising safe preventive agent for AD with antioxidant, anti-inflammatory, anti-acetylcholinesterase, and anti-amyloidogenic activities. The LC/MS/MS analysis for the two Hibiscus extracts identified anthocyanins, flavonoids, and aliphatic and phenolic acids as being the major components responsible for the neuroprotective activity [ 207 ].…”

Section: Neuroprotective Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

101

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice

Cited by 49 publications

References 49 publications

Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders

Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders

Olive Leaves and Hibiscus Flowers Extracts-Based Preparation Protect Brain from Oxidative Stress-Induced Injury

Neuroprotective Natural Products for Alzheimer’s Disease

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