Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice

Vilela, Thais Ceresér; Leffa, Daniela Dimer; Damiani, Adriani Paganini; Damazio, Daiane Dal Col; Manenti, Aline V.; Carvalho, Tiago José Griebeler; Ramlov, Fernanda; Amaral, P. A.; Andrade, Vanessa Moraes de

doi:10.1590/0001-3765201820180144

Cited by 5 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chlorogenic acid (CGA), caffeic acid (CA), delphinidin-3-sambubioside (Dp3-Sam), delphinidin-3-glucoside (Dp3-Glu), cyanidin-3-sambubioside (Cy3-Sam), all obtained from Sigma-Aldrich Co. (St. Louis, MO, USA) were identified based on the retention times of commercial standards (UV spectrum). Gallocatechin (GC) and gallic acid (GAL) were identified as described in a previous study [ 16 ] and by their UV-visible spectral characteristics.…”

Section: Methodsmentioning

confidence: 99%

“…In terms of pharmacological effects, Hibiscus plants have also attracted interest because of their biological activities, which include antibacterial, anti-inflammatory, antigenotoxic, hepatoprotective, and antimutagenic activities [ 13 , 14 , 15 , 16 ]. In particular, the antibacterial activity of H. sabdariffa has been well-studied as well as other biological activities of extracts of its leaves and flowers [ 4 , 17 , 18 ], while H. acetosella has been reported as having anti-inflammatory [ 12 ] and antimutagenic activity [ 16 ], but no antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phenolic Compounds in Extracts of Hibiscus acetosella (Cranberry Hibiscus) and Their Antioxidant and Antibacterial Properties

et al. 2020

View full text Add to dashboard Cite

Hibiscus species are rich in phenolic compounds and have been traditionally used for improving human health through their bioactive activities. The present study investigated the phenolic compounds of leaf extracts from 18 different H. acetosella accessions and evaluated their biofunctional properties, focusing on antioxidant and antibacterial activity. The most abundant phenolic compound in H. acetosella was caffeic acid, with levels ranging from 14.95 to 42.93 mg/100 g. The antioxidant activity measured by the ABTS assay allowed the accessions to be classified into two groups: a high activity group with red leaf varieties (74.71–84.02%) and a relatively low activity group with green leaf varieties (57.47–65.94%). The antioxidant activity was significantly correlated with TAC (0.933), Dp3-Sam (0.932), Dp3-Glu (0.924), and Cy3-Sam (0.913) contents (p < 0.001). The H. acetosella phenolic extracts exhibited antibacterial activity against two bacteria, with zones of inhibition between 12.00 and 13.67 mm (Staphylococcus aureus), and 10.67 and 13.33 mm (Pseudomonas aeruginosa). All accessions exhibited a basal antibacterial activity level (12 mm) against the Gram-positive S. aureus, with PI500758 and PI500764 exhibiting increased antibacterial activity (13.67 mm), but they exhibited a more dynamic antibacterial activity level against the Gram-negative P. aeruginosa.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds in Extracts of Hibiscus acetosella (Cranberry Hibiscus) and Their Antioxidant and Antibacterial Properties

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recently, Vilela et al (2018) [159] analyzed the presence of phenolic compounds in extracts of H. acetosella leaves (EHa) by high-performance liquid chromatography (HPLC) and determined the antigenotoxic effect of these extracts against the damage produced by methyl methanesulfonate (MMS) in mice. The HPLC results showed the presence of caffeic acid, gallic acid, gallocatechin, coumaric acid, and 3,4-dihydroxybenzoic acid.…”

Section: Antigenotoxic Plants and Vegetablesmentioning

confidence: 99%

“…The HPLC results showed the presence of caffeic acid, gallic acid, gallocatechin, coumaric acid, and 3,4-dihydroxybenzoic acid. On the other hand, using the micronucleus test and the comet assay, they showed that the animals treated with EHa (dose of 50 mg/kg or 100 mg/kg) plus the alkylating agent significantly decreased the DNA damage [159].…”

Section: Antigenotoxic Plants and Vegetablesmentioning

confidence: 99%

Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin

et al. 2018

View full text Add to dashboard Cite

Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.

show abstract

“…HA leaves extracts had potential in antioxidant and free radical scavenging properties at various solvent extractions (water, methanol, and ethanol). All of extracts had good ability to scavenge and reducing power to eliminate free radicals which may be the potential of anthocyanin content in HA leaves according to previous studies that indicated the plants in Hibiscus genus always showed the antioxidant, anti-inflammation, anticancer properties and have the potentials in free radical scavenging, due to their chemical constituents which consist of flavonoids and polyphenolic compounds [23]. The differentiation of extract solvents was a factor which effected to the ability in antioxidant of the extracts.…”

Section: Resultsmentioning

confidence: 86%

Antioxidant and Free Radical Scavenging Activity of Hibiscus Acetosella Leaves Extracts

Dumrongphuttidecha¹,

Thungmungmee²,

Khobjai³

et al. 2019

Int J App Pharm

View full text Add to dashboard Cite

Objective: Hibiscus acetosella (HA) or Chaba Maple is native plant and cultivated in tropical western in Africa and north of America. The characteristicsof HA are red to purple in stem, leaf, and flower that are the pigment of antioxidant compound as anthocyanins. Anthocyanins are in the groupof flavonoid and have the role as functional foods which have several health benefits such as obesity and diabetes control, cardiovascular diseaseprevention, and others. Hence, the aim of this study was to investigate the antioxidant and free radical scavenging activity of HA leaves extracts.Materials and Methods: HA (Chaba Maple) leaves were collected in Pathum Thani province, Thailand, and were dried and extracted by macerationtechnique with three solvents – water, ethanol, and methanol. The antioxidant properties of extracts were carried out using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay and ferric reducing antioxidant power (FRAP) assay. The extracts wereexamined for their scavenging effect on hydroxyl radical (•OH) using hydroxyl radical scavenging assay and nitric oxide (NO) radical (•NO) using NOradical scavenging assay.Results: For ABTS, FRAP, and hydroxyl radical scavenging assay, ethanol extract showed the highest antioxidant property which the percentageinhibitions were 69.04%, 2381.84 μM/mg extract, and 62.88 mg/ml, respectively. For NO scavenging activity, methanol extract showed highest abilityto scavenge NO which percentage inhibition was 101.28±0.73 mg/ml.Conclusion: The results of this study showed that ethanolic, methanolic, and water extract of HA leaves had scavenge and reducing antioxidantproperties.

show abstract

Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice

Cited by 5 publications

References 29 publications

Phenolic Compounds in Extracts of Hibiscus acetosella (Cranberry Hibiscus) and Their Antioxidant and Antibacterial Properties

Phenolic Compounds in Extracts of Hibiscus acetosella (Cranberry Hibiscus) and Their Antioxidant and Antibacterial Properties

Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin

Antioxidant and Free Radical Scavenging Activity of Hibiscus Acetosella Leaves Extracts

Contact Info

Product

Resources

About