HGF/c-Met Axis: The Advanced Development in Digestive System Cancer

Shao, Zhiwei; Pan, Heng; Tu, Sheng; Zhang, Jingying; Yan, Sheng; Shao, Anwen

doi:10.3389/fcell.2020.00801

Cited by 11 publications

(18 citation statements)

References 113 publications

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“…In previous studies, the HGF/c-Met signaling pathway is a key factor in tumor progression [8,22]. We found that MACC1 is an important activator of c-Met.…”

Section: Discussionsupporting

confidence: 50%

“…Under normal physiological conditions, HGF/c-Met can mediate embryonic development, cell proliferation, injured tissue repair, and neuromuscular formation [7]. A large number of studies have shown that the overactivation of c-Met may initiate the transformation of normal cells to tumor cells and further promote the occurrence of subsequent events such as invasion, metastasis, and diffusion [8]. c-Met is the encoding HGF receptor gene, located in 7q21-q31 on human chromosome 7; is a transmembrane receptor protein tyrosine kinase; and is expressed mainly in the epithelial tissue [9].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Shi

Wang

et al. 2022

Analytical Cellular Pathology

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Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its adjacent tissues. Statistical analysis was done by SPSS 23.0. Results. The high expression of MACC1 and cyclin D1 was significantly correlated with tumor size. High c-Met expression was associated with patient ethnicity. MACC1 expression was positively correlated with both c-Met and cyclin D1. c-Met expression was also positively correlated with cyclin D1. Patients with high expression of MACC1 and c-Met had worse OS; patients with high c-Met expression also had worse PFS. Conclusion. MACC1, c-Met, and cyclin D1 proteins are closely related to the occurrence and development of esophageal squamous cell carcinoma. MACC1 may affect the prognosis of ESCC by regulating the expression of the c-Met/cyclin D1 axis.

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“…In previous studies, the HGF/c-Met signaling pathway is a key factor in tumor progression [8,22]. We found that MACC1 is an important activator of c-Met.…”

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

Shi

Wang

et al. 2022

Analytical Cellular Pathology

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“…In non-malignant situations, hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling is essential for embryogenesis, muscle development, nervous system formation, hematopoietic cell differentiation, and bone remodeling [19,20]. In malignant disease, the activation of the HGF/MET signal pathway results in cell proliferation, survival, inhibition of apoptosis, migration, invasion, and metastasis [21][22][23]. This is also true for UM.…”

Section: Introductionmentioning

confidence: 99%

The Role of HGF/MET Signaling in Metastatic Uveal Melanoma

Tanaka

Terai

Londin

et al. 2021

Cancers

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Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signaling promotes tumorigenesis and tumor progression in various types of cancer, including uveal melanoma (UM). The roles of HGF/MET signaling have been studied in cell survival, proliferation, cell motility, and migration. Furthermore, HGF/MET signaling has emerged as a critical player not only in the tumor itself but also in the tumor microenvironment. Expression of MET is frequently observed in metastatic uveal melanoma and is associated with poor prognosis. It has been reported that HGF/MET signaling pathway activation is the major mechanism of treatment resistance in metastatic UM (MUM). To achieve maximal therapeutic benefit in MUM patients, it is important to understand how MET signaling drives cellular functions in uveal melanoma cells. Here, we review the HGF/MET signaling biology and the role of HGF/MET blockades in uveal melanoma.

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“…For example, among the reported c-Met inhibitors, crizotinib and cabozantinib are approved for the treatment of nonsmall-cell lung cancer and medullary thyroid cancer. 22 – 29 To date, no selective c-Met kinase inhibitors have been approved for clinical use. Based on the inhibitory results from the ELISA kinase assay, chalcone-1,3,4-thiadiazole hybrid ZW97 selectively and potently inhibited c-Met kinase with an IC 50 of 27.96 nM.…”

Section: Discussionmentioning

confidence: 99%

A novel anti-lung cancer agent inhibits proliferation and epithelial–mesenchymal transition

Zhao

Guo

et al. 2022

J Int Med Res

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Objective To synthesize a novel chalcone-1,3,4-thiadiazole hybrid and investigate its anticancer effects against NCI-H460 cells. Methods ( E)-3-(4-bromophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 1,3-dibromopropane and 1,3,4-thiadiazole-2-thiol were used as chemical materials to synthesize compound ZW97. The NCI-H460 lung cancer cell line was selected to explore the antitumor effects of compound ZW97 in vitro and in vivo. Results Compound ZW97 selectively inhibited cell proliferation against lung cancer cell lines NCI-H460, HCC-44 and NCI-H3122 with IC50 values of 0.15 μM, 2.06 μM and 1.17 μM, respectively. ZW97 suppressed migration and the epithelial–mesenchymal transition process in NCI-H460 cells in a concentration-dependent manner. Based on the kinase activity results and docking analysis, compound ZW97 is a novel tyrosine-protein kinase Met (c-Met kinase) inhibitor. It also inhibited NCI-H460 cell growth in xenograft models without obvious toxicity to normal tissues. Conclusions Compound ZW97 is a potential c-Met inhibitor that might be a promising agent to treat lung cancer by inhibiting the epithelial–mesenchymal transition process.

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HGF/c-Met Axis: The Advanced Development in Digestive System Cancer

Cited by 11 publications

References 113 publications

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC

The Role of HGF/MET Signaling in Metastatic Uveal Melanoma

A novel anti-lung cancer agent inhibits proliferation and epithelial–mesenchymal transition

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