HGF and MET: From Brain Development to Neurological Disorders

Desole, Claudia; Gallo, Simona; Vitacolonna, Annapia; Montarolo, Francesca; Bertolotto, Antonio; Vivien, Denis; Comoglio, Paolo M.; Crepaldi, Tiziana

doi:10.3389/fcell.2021.683609

Cited by 61 publications

(50 citation statements)

References 219 publications

(282 reference statements)

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“…Several upregulated biomarkers, identified in the present study, act on the central nervous system promoting protection or damage to the brain. HGF is a neuronal growth and survival factor capable of preventing neuronal death through its pro-angiogenic, anti-inflammatory and immunoregulatory activities and stimulating neuroregeneration by acting on neural stem cells and also promoting synaptogenesis [59]. Also part of the comprehensive multiplex assay, another relevant biomarker found in the present study was NGF, which has anti-inflammatory and homeostatic properties in the central nervous system [60].…”

Section: Discussionmentioning

confidence: 70%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

et al. 2022

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People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18 FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

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Section: Discussionmentioning

confidence: 70%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

et al. 2022

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“…HGF also promotes synaptogenesis [86]. The presence of HGF might mean a sign of pre-conditions to recover after a multifaceted brain injury [86]. Another relevant biomarker found in the present study was NGF, which has anti-inflammatory properties in the central nervous system [87].…”

Section: Discussionmentioning

confidence: 80%

“…HGF is a neuronal growth and survival factor capable of preventing neuronal death through its pro-angiogenic, anti-inflammatory and immunoregulatory activities and stimulating neuroregeneration by acting on neural stem cells. HGF also promotes synaptogenesis [86]. The presence of HGF might mean a sign of pre-conditions to recover after a multifaceted brain injury [86].…”

Section: Discussionmentioning

confidence: 99%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Paula

Paiva

Silva

et al. 2022

Preprint

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People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

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“…Specifically, PTX3, an activator of the A2 astrocytes, mediates neurogenesis and helps restore nerve function via angiogenesis [40,41]. bFGF supports the growth of nerve cells and neural stem cells and can protect nerves [42], whereas HGF can prevent neuronal cell death [43]. Furthermore, KLK3 can promote neurite outgrowth [44], and IL-8 increases neuronal survival [45].…”

Section: Devs-f12 Promotes Neuronal Differentiation Of Npcs By Alteri...mentioning

confidence: 99%

Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cells

Park

Kim

et al. 2022

IJMS

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Mesenchymal stem cells (MSCs) have been adopted in various preclinical and clinical studies because of their multipotency and low immunogenicity. However, numerous obstacles relating to safety issues remain. Therefore, MSC-derived extracellular vesicles (EVs) have been recently employed. EVs are nano-sized endoplasmic reticulum particles generated and released in cells that have similar biological functions to their origin cells. EVs act as cargo for bioactive molecules such as proteins and genetic materials and facilitate tissue regeneration. EVs obtained from adipose-derived MSC (ADMSC) also have neuroprotective and neurogenesis effects. On the basis of the versatile effects of EVs, we aimed to enhance the neural differentiation ability of ADMSC-derived EVs by elucidating the neurogenic-differentiation process. ADMSC-derived EVs isolated from neurogenesis conditioned media (differentiated EVs, dEVs) increased neurogenic ability by altering innate microRNA expression and cytokine composition. Consequently, dEVs promoted neuronal differentiation of neural progenitor cells in vitro, suggesting that dEVs are a prospective candidate for EV-based neurological disorder regeneration therapy.

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HGF and MET: From Brain Development to Neurological Disorders

Cited by 61 publications

References 219 publications

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cells

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