HFE Genotype Modifies the Influence of Heme Iron Intake on Iron Status

Dc, Greenwood; Cade, Janet; Ja, Moreton; O'Hara, Beverley; Burley, Victoria J.; Randerson-Moor, Juliette; Kukalizch, Kairen; Thompson, Deborah J.; Worwood, Mark; Bishop, D. Timothy

doi:10.1097/01.ede.0000181306.85583.ea

Cited by 18 publications

(18 citation statements)

References 14 publications

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“…However, dietary heme iron intake did not enter significantly into the equation (data not shown). This contrast with several reports suggesting that heme iron ingestion affect iron status and absorption in individuals with HFE mutations [34, 38, 43], however heme iron intake in our population was moderate (mean, 3.6 mg/day). It would appear that there is a decrease in the control of iron absorption in subjects heterozygous for C282Y [44], allowing its absorption from diets rich in bioavailable iron.…”

Section: Discussioncontrasting

confidence: 99%

Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

et al. 2010

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Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk populations. Polymorphisms of the HFE gene (C282Y, H63D and S65C) were measured together with serum ferritin (SF), transferrin saturation (TS) and hemoglobin, to measure iron status, in randomly-selected healthy subjects living in the Spanish Mediterranean coast (n = 815; 425 females, 390 males), 18 to 75 years of age. The intake of dietary components that affect iron absorption was calculated from 3-day dietary records. The presence of C282Y/H63D compound heterozygote that had a prevalence of 2.8% in males and 1.2% in females was associated with an elevated TS and SF. No subject was homozygous for C282Y or S65C. The C282Y heterozygote, H63D heterozygote and homozygote and H63D/S65C compound heterozygote genotypes were associated with increased TS relative to the wild type in the general population. These genotypes together with the alcohol and iron intake increase the indicators of iron status, while calcium intake decreases them. We did not observe any affect of the S65C heterozygote genotype on these levels. All the HFE genotypes except for the S65C heterozygote together with the alcohol, iron and calcium intake affect the indicators of iron status. The C282Y/H63D compound heterozygote genotype has the higher phenotypic expression in our Spanish Mediterranean population.

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Section: Discussioncontrasting

confidence: 99%

Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

et al. 2010

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“…The association of heme iron intake with SF levels estimated by the use of food frequency questionnaires (from meat, fish, and poultry) was 2.0 times greater (range, 1.2-3.2) in C282Y homozygotes than subjects with other HFE genotypes; estimated nonheme iron intake had little effect on SF levels. 69,70 In women in The Netherlands older than 50 years of age, C282Y homozygotes (and C282Y/H63D compound heterozygotes) had significantly greater SF concentrations than women with other HFE genotypes. C282Y homozygotes and C282Y/H63D compound heterozygotes who consumed relatively high amounts of heme iron had the greatest SF concentrations.…”

Section: Ironmentioning

confidence: 95%

How I treat hemochromatosis

Adams

Barton

2010

Blood

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Hemochromatosis is a common genetic disorder in which iron may progressively accumulate in the liver, heart, and other organs. The primary goal of therapy is iron depletion to normalize body iron stores and to prevent or decrease organ dysfunction. The primary therapy to normalize iron stores is phlebotomy. In this opinion article, we discuss the indications for and monitoring of phlebotomy therapy to achieve iron depletion, maintenance therapy, dietary and pharmacologic maneuvers that could reduce iron absorption, and the role of voluntary blood donation. (Blood. 2010;116(3):317-325)

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“…Mutations in genes other than HFE are associated with severe hemochromatosis phenotypes in a small percentage of C282Y homozygotes and other persons (1,3,11,(17)(18)(19)(20). In some cases, thalassemia or other heritable forms of anemia, dietary factors, blood loss, or conditions that decrease iron absorption may modify iron phenotypes (21)(22)(23)(24)(25)(26)(27)(28)(29).…”

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confidence: 99%

A genome‐wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study

et al. 2007

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Iron overload phenotypes in persons with and without hemochromatosis are variable. To investigate this further, probands with hemochromatosis or evidence of elevated iron stores and their family members were recruited for a genome-wide linkage scan to identify potential quantitative trait loci (QTL) that contribute to variation in transferrin saturation (TS), unsaturated iron-binding capacity (UIBC), and serum ferritin (SF). Genotyping utilized 402 microsatellite markers with average spacing of 9 cM. A total of 943 individuals, 64% Caucasian, were evaluated from 174 families. After adjusting for age, gender, and race/ethnicity, there was evidence for linkage of UIBC to chromosome 4q logarithm of the odds (LOD) = 2.08, p = 0.001) and of UIBC (LOD = 9.52), TS (LOD = 4.78), and SF (LOD = 2.75) to the chromosome 6p region containing HFE (each p < 0.0001). After adjustments for HFE genotype and other covariates, there was evidence of linkage of SF to chromosome 16p (LOD = 2.63, p = 0.0007) and of UIBC to chromosome 5q (LOD = 2.12, p = 0.002) and to chromosome 17q (LOD = 2.19, p = 0.002). We conclude that these regions should be considered for fine mapping studies to identify QTL that contribute to variation in SF and UIBC.

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HFE Genotype Modifies the Influence of Heme Iron Intake on Iron Status

Abstract: There may be scope for dietary intervention in women homozygous for the C282Y mutation. C282Y heterozygotes and H63D homozygotes and heterozygotes have similar serum ferritin concentrations to wild type and need not reduce their meat intake other than as part of a normal healthy diet.

Cited by 18 publications

References 14 publications

Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

How I treat hemochromatosis

A genome‐wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study

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