Hezbollah

Wahab, Hadi

doi:10.26756/th.2017.30

Cited by 2 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…9 Boswellia gum resins are complex mixtures, and crude organic extracts thereof contain a mixture of natural mono-, sesqui-, di-, and triterpenes. [10][11][12][13][14] The normally occurring penta-and tetracyclic triterpenes consist of structurally related members, which, depending on the nature of functional groups, can exert an inhibitory, partial inhibitory, noninhibitory, or even a potentiating influence upon the LT biosynthesis. 4,15,16 In addition, partial-inhibitory and noninhibitory terpenes antagonize AKBA inhibition of 5-LO by competitive binding to 5-LO.…”

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confidence: 99%

Workup-Dependent Formation of 5-Lipoxygenase Inhibitory Boswellic Acid Analogues

et al. 2000

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Pentacyclic triterpenes from the 11-keto-boswellic acid series were identified as the active principal ingredients of Boswellia resin, inhibiting the key enzyme of leukotriene biosynthesis, 5-lipoxygenase (5-LO). Of the genuine boswellic acids hitherto characterized, 3-O-acetyl-11-keto-beta-boswellic acid, AKBA (1), proved to be the most potent inhibitor of 5-LO. In the course of purification of further boswellic acid derivatives from Boswellia resin, we observed the degradation of the natural compound 3-O-acetyl-11-hydroxy-beta-boswellic acid (2) to the thermodynamically more stable product 3-O-acetyl-9, 11-dehydro-beta-boswellic acid (4). The metastable intermediate of this conversion, under moderate conditions of workup in methanolic solutions, was identified as 3-O-acetyl-11-methoxy-beta-boswellic acid (3). The novel artifactual boswellic acid derivatives inhibited 5-LO product formation in intact cells with different characteristics: 4 almost totally abolished 5-LO activity, with an IC(50) of 0.75 microM, whereas 3 and 9,11-dehydro-beta-boswellic acid (5), the deacetylated analogue of 4, were incomplete inhibitors. The data suggest that the conditions chosen for the workup of Boswellia extracts could significantly influence the potency of their biological actions and their potential therapeutic effectiveness.

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Workup-Dependent Formation of 5-Lipoxygenase Inhibitory Boswellic Acid Analogues

et al. 2000

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“…The present study was performed to compare the analgesic and anti-inflammatory efficacy of tenoxicam, with that of diclofenac sodium following third molar surgery. With a rich case bank established over 3 decades we have been able to publish extensively in our domain [1,2,3,4,5,6,7,8,9,10,11].…”

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Evaluation of the Effect of Tenoxicam Compared to Diclofenac Sodium in Controlling Postoperative Pain in Third Molar Surgery

Thota

Periasamy

Mahathi

2021

JPRI

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Aim: The aim of this study is to evaluate the effect of tenoxicam compared to diclofenac sodium in controlling postoperative pain after third molar surgery. Materials and Methods: 36 patients with mean age 30 were selected randomly and placed them in two groups A and B, under group A there are 18 patients and in group B 18 patients were placed, group a is given with tenoxicam 30 mg and for group b diclofenac sodium 50 mg. Results: Group A experienced significantly less pain than those patients in group b. at 24 hr on the day of surgery, average pain scores of patients in both treatment groups did not differ significantly. On the evening of the third day postoperatively, the group a (tenoxicam) patients experienced significantly less pain than those in group b (diclofenac sodium). Discussion: It is generally accepted that pain following third molar surgery reaches moderate to severe intensity within the first 5 hr after surgery. Pain control in this period is thus of vital importance to the oral surgeon. NSAIDs have shown considerable analgesic activity for the relief of pain after surgery. Prostaglandin concentrations do not peak until 4 hr after surgical trauma. tenoxicam has been shown in our study to produce significant analgesia when compared to diclofenac sodium, especially at 3 to 4 hr postoperatively, the period when there is maximum prostaglandin formation in the tissue. Conclusion: Tenoxicam as administered in the present study was significantly more efficacious than diclofenac sodium and useful for pain control in these cases.

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Hezbollah

Cited by 2 publications

References 4 publications

Workup-Dependent Formation of 5-Lipoxygenase Inhibitory Boswellic Acid Analogues

Workup-Dependent Formation of 5-Lipoxygenase Inhibitory Boswellic Acid Analogues

Evaluation of the Effect of Tenoxicam Compared to Diclofenac Sodium in Controlling Postoperative Pain in Third Molar Surgery

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