Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
Jia-Jun Wu,
Shu-Yan Zhang,
Lin Mu
et al.
Abstract:BACKGROUND
Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR.
AIM
To determine the HYWZF prevention mechanisms, especially those underlying mitophagy.
METHODS
Human retinal capillary endothelial cells (HRCECs) were treated with high glucose (hg), HYWZF serum, PX-478, or Mdivi-1 in vitro . Then, cell counting kit-8, transwell, and tube formation assays were used… Show more
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