Hexosamine metabolism I. The absoption and metabolism, in vivo, of orally administered d-glucosamine and N-acetyl-d-glucosamine in the rat

Capps, Jerry C.; Shetlar, M. R.; Bradford, Reagan H.

doi:10.1016/0304-4165(66)90489-2

Cited by 24 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…bioavailability are inconclusive. In one study, the authors used radiolabelled glucosamine and measured exhaled radioactivity by control and antibiotic‐treated rats 27. They found pulmonary excretion of radioactivity in the latter group, suggestive of a greater exposure in the antibiotic‐treated rats.…”

Section: Discussionmentioning

confidence: 99%

Absorption and Bioavailability of Glucosamine in the Rat

Ibrahim

Kohan

Aghazadeh‐Habashi

et al. 2012

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Absorption and Bioavailability of Glucosamine in the Rat

Ibrahim

Kohan

Aghazadeh‐Habashi

et al. 2012

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…of 250,uCi of [1-14C]glucosamine. Previous work has shown that this label is incorporated mainly into glucosamine residues (at least 70 % of the total label) with the remainder in sialic acid moieties (Shetlar et al, 1961(Shetlar et al, , 1964Winzler, 1965;Capps et al, 1966;Robinson, 1968). Blood was obtained by cardiac puncture and plasma separated by centrifugation.…”

mentioning

confidence: 99%

Studies on bone matrix glycoproteins. Incorporation of [1-14C]glucosamine and plasma [14C]glycoprotein into rabbit cortical bone

Triffitt

Owen

1973

Biochemical Journal

View full text Add to dashboard Cite

The radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. Plasma [(14)C]glycoprotein labels the less acidic glycoproteins to a greater extent than the more acidic components. An antibody has been raised against the less-acidic-glycoprotein fraction of bone. The latter contains a glycoprotein of alpha-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. This alpha-glycoprotein accounts for a large proportion of the components labelled and retained in bone matrix after [(14)C]glucosamine injection.

show abstract

“…It has been reported that GlcN is rapidly absorbed after oral administration (Persiani et al 2005;Pashkova et al 2009). The absorption rate of the intact form of GlcNAc is lower than GlcN and appreciable amounts of GlcNAc would be deacetylated during the intestinal absorption (Liu et al 2008;Capps et al 1966;Robinson 1968). In the present study, oral administration of GlcN-HCl or GlcNAc significantly reduced the levels of histamine in plasma and ear in DNFB-treated mice.…”

Section: Discussionmentioning

confidence: 98%