Hexavalent chromium induces testicular dysfunction in small Indian mongoose (Herpestes javanicus) inhabiting tanneries area of Kasur District, Pakistan

Andleeb, Shaista; Mahmood, Tariq; Khalid, Azeem; Akrim, Faraz; Fatima, Hira

doi:10.1016/j.ecoenv.2017.11.075

Cited by 20 publications

(9 citation statements)

References 24 publications

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“…In the scenario of already reported clinical malnutrition studies, in animals exposed to control Cr doses, such as studied by National Toxicology Program (NTP, 2008), and clinical symptoms observed in animals as well as the potential impairment of reproductive functioning of the species (Andleeb et al, 2018), the findings of the current study indicate that elevated Cr concentration in the environment can lead to altered reproductive endpoints in the exposed female small Indian mongooses.…”

Section: Discussionsupporting

confidence: 50%

“…Based on (Andleeb et al, 2018) findings, soil and water Cr concentrations were found significantly elevated in the environment. Among the five different selected experimental sites, mean values of Cr in soil and water samples did not differ; however, experimental sites showed significant differences in Cr concentrations (soil and water) compared to control (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Water and soil samples were collected and analyzed in our previous published study (Andleeb et al, 2018). During the current study, we used live traps at the selected sites to capture female mongooses from selected sampling sites; two adult female mongooses were captured each month from the study area, the specimens were brought to the laboratory and killed to collect blood and body tissues (including ovaries, liver and kidneys).…”

Section: Sample Collectionmentioning

confidence: 99%

“…Cr concentrations (mean + SE) in soil, water (as previously published paper byAndleeb et al, 2018), and body tissues of small Indian mongoose from Kasur district during the study period (February 2015 to January 2016). *p < 0.05; **p < 0.01; ***p < 0.001.…”

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confidence: 95%

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Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

2019

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The populations of wild animals are declining in many parts of the world in response to man-made alterations in the environment. Environmental contamination due to heavy metals discharge from industry may contribute to the decline of wild animal populations by impacting their reproduction, growth, and development. In the leather tanning industry, chromium (Cr) is used as a basic component, but it is a potent toxicant that can affect many of the physiological functions of animals. In the current study, we investigated the reproductive toxicity of industrial Cr in female small Indian mongooses inhabiting a tannery area. Adult female specimens were live trapped from February 2015 to January 2016. Blood and other body tissues (ovaries, kidneys and liver) of the captured specimens were collected along with soil and water samples from the environment for analysis. The Cr concentrations were found significantly (p < 0.0001) increased compared to control in the environment, blood, and all body tissues of the animals. Estradiol and progesterone levels were found to be significantly decreased in comparison with control (p < 0.0001), along with reduced ovarian weights, while follicle stimulating hormone (FSH) and luteinizing hormone levels were found significantly (p < 0.0001) elevated. Light microscopy revealed significantly decreased in comparison with control ovarian follicle numbers (p < 0.0001) and diameters, vacuolization of the oocytes, and a significantly higher percentage of atretic follicles inside the ovary. We conclude that Cr discharged from the tanneries is absorbed by the exposed female small Indian mongoose, leading to ovarian dysfunction with potential impairment of reproductive function.

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Section: Discussionsupporting

confidence: 50%

Section: Resultsmentioning

confidence: 99%

Section: Sample Collectionmentioning

confidence: 99%

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Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

2019

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“…Also, Marouani et al suggested that CrVI subacute treatment causes oxidative stress in rat testis leading to apoptosis . Also, Andleeb et al concluded that Cr exposure leads to testicular injury in mongooses and potential disturbances in reproductive system since they showed disorganization of seminiferous tubules, and decreased numbers of Sertoli and the Leydig cells in addition to spermatozoa and seminiferous tubular counts . Similar studies showed significant spermatid degradation after Cr administration and this may be attributed to the injury of testes blood barrier along with Cr accumulation in the animal testis or may be due to the generation of ROS with disturbance in antioxidant defense system …”

Section: Discussionmentioning

confidence: 95%

Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and/or hexavalent chromium in rats

El‐Demerdash

Jebur

Nasr

et al. 2018

Environmental Toxicology

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Oxidative stress and increased production of reactive oxygen species have been implicated in pesticides and heavy metals toxicity. The objective of this study was to investigate the efficacy of Turnera diffusa Willd (damiana) on counteracting fenitrothion (FNT) and/or potassium dichromate (CrVI)-induced testicular toxicity and oxidative injury in rats. FNT and/or CrVI intoxicated animals revealed a significant increase in thiobarbituric acid reactive substances and hydrogen peroxide levels. While, reduced glutathione and protein content, as well as antioxidant enzymes, phosphatases, and aminotransferases activities, were significantly decreased. In addition, significant changes in testosterone and follicle-stimulating hormone levels were detected. Furthermore, histological and immunohistochemical alterations were observed in rat testes and this supported the observed biochemical changes. On the other hand, rats treated with damiana alone decreased lipid peroxidation and increased most of the examined parameters. Moreover, damiana pretreatment to FNT and/or CrVI-intoxicated rats showed significant improvement in lipid peroxidation, enzyme activities, and hormones as compared with their respective treated groups. Conclusively, rats treated with both FNT and/or CrVI showed pronounced hazardous effect especially in their combination group in addition, Turnera diffusa had a potential protective role against FNT and/or CrVI induced testicular toxicity. K E Y W O R D Schromium hexavalent, fenitrothion, oxidative stress, rat testes, Turnera diffusa

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Evaluation of heavy metals effects on morpho‐anatomical alterations of wheat (Triticum aestivum L.) seedlings

Nazir

Rafique

Ahmed

et al. 2021

Microscopy Res & Technique

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The present study aimed to evaluate the effects of Cd and Cr as separate and in combinations in hydroponically grown seedlings of FA‐08 and SH‐13 cultivars of wheat (Triticum aestivum L.). The concentrations of heavy metals were higher in the root as compared to shoot and were more pronounced in SH‐13 than FA‐08 cultivar. The decrease in the seedling length and biomass was observed when the metals were applied in combined form (Cd–Cr 80–120, Cd–Cr 100–120, Cr–Cd 140–80, and Cr–Cd 140–100). There were more declines in root length in the cultivar SH‐13 as compared to the shoot length, as the concentration of HMs increased. The root at level Cr‐140 and shoot at level Cd‐100 showed more reduction in SH‐13 than FA‐08. The high concentration of Cd and Cr affected the root epidermis, the cortical cells, and the xylem vessel. The size and number of stomata, length of long cells and short cells, and trichome were reduced at the concentration Cd‐100 and Cr‐140. The present study showed that the higher concentration of Cd and Cr affects the morpho‐anatomical features of both selected wheat cultivar moderately.

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Hexavalent chromium induces testicular dysfunction in small Indian mongoose (Herpestes javanicus) inhabiting tanneries area of Kasur District, Pakistan

Cited by 20 publications

References 24 publications

Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and/or hexavalent chromium in rats

Evaluation of heavy metals effects on morpho‐anatomical alterations of wheat (Triticum aestivum L.) seedlings

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