Hexavalent chromium disrupts chromatin architecture

VonHandorf, Andrew; Zablon, Hesbon A; Puga, Alvaro

doi:10.1016/j.semcancer.2021.07.009

Cited by 18 publications

(12 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cr-DNA formation adducts can lead to chromosome fragmentation and mutagenesis (Zhitkovich, 2011). Earlier studies have shown that Cr(VI) compounds can produce different types of DNA damage, such as single-strand breaks, base instability sites, and DNA-protein crosslinks, while selectively inhibiting the activity of enzymes, such as glutathione reductase (VonHandorf et al, 2021). An increase in Cr(VI) level leads to oxidative damage to tissues, and oxidative damage generates large amounts of ROS; overproduction of ROS an lead to deleterious biological effects and irreversible damage by promoting the oxidation of proteins, lipids, carbohydrates, and DNA (Scharf et al, 2014).…”

Section: Genotoxicitymentioning

confidence: 99%

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Yan

Ying-jun

Xue

et al. 2023

Front. Environ. Sci.

View full text Add to dashboard Cite

Chromium (Cr) is the seventh most abundant chemical element in the Earth’s crust, and Cr(III) and Cr(VI) are common stable valence states of Cr. Several Cr-containing substances, such as FeOCr2O3 and stainless-steel products, exist in nature and in life. However, Cr(VI) is toxic to soil, microorganisms, and plants and poses a serious threat to human health through direct and indirect exposure. By collecting published journal literature, we found that Cr(VI) can cause acute and chronic toxicity in organisms and has carcinogenic effects, and the mechanisms causing these toxicity include endoplasmic reticulum stress, autophagy and apoptosis. However, the relationship between these mechanisms remains unclear. Many methods have been researched to purify chromium, but each of these methods has its own advantages and disadvantages. Therefore, this review summarizes the hazards of chromium and the mechanisms of chromium toxicity after entering cells and provides a number of methods for chromium contamination management, providing a direction for the next step in chromium toxicology and contamination decontamination research.

show abstract

Section: Genotoxicitymentioning

confidence: 99%

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Yan

Ying-jun

Xue

et al. 2023

Front. Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…Moreover, chromium toxicity depends on chemical specificity, thus the health related effect of chromium is concerned by the chemical form of exposure. It is well known that chromium (VI) is a potentially toxic substance to humans, animals, and microbes because it enters the cell via the surface transport system and is reduced to the level of chromium (III) which is associated with the breakdown of DNA (Shi et al 2021;VonHandorf et al 2021).…”

Section: Chemical Texture Of Twwmentioning

confidence: 99%

Phytoremediation of chromium, iron and nickel by Indian Rice Plant (Oryza sativa L.): An opportunity for management of multi-metal contaminated tannery wastewaterPhytoremediation of chromium, iron and nickel by Indian Rice Plant (Oryza sativa L.): An opportunity for management of multi-metal contaminated tannery wastewater

et al. 2022

View full text Add to dashboard Cite

India is the largest producer of leather and leather products. Tannery industries use a large number of synthetic chemicals for the processing of leather and generate a huge amount of wastewater containing a large amount of potentially toxic heavy metals (PTHMs) making them problematic for next-door soil and water system. Currently, phytoremediation is an inexpensive green technology used to move, eradicate, and stabilized heavy metal contamination from contaminated sludge, soil, and wastewater. In this study, the accumulation and distribution of PTHMs found in tannery wastewater and their physio-biochemical effects on Oryza sativa L. have been studied by ICP-MS, GC-MS, and biochemical analysis. The plant was grown in the soil spiked with a mixture of metals (Cr, Fe and Ni) and their five-level of treatment T1 (25mg/kg); T2 (50mg/kg); T3 (100mg/kg); T4 (200mg/kg) and T5 (400mg/kg). During the experiments, various morphological attributes, oxidative stress, enzymatic activities, chlorophyll, and protein content at the different stage was measured. Further, metal accumulation pattern in different parts of plants was also measured. Results of the study revealed that plant root, shoot length, chlorophyll content, and enzymatic activities were significantly reduced after the treatment with 200 mg/kg PTHMs; whereas oxidative stress was increase compared to control levels. Further, treatment of PTHMs suggested that the rice plant (Oryza sativa L.) is well adapted to tolerate and accumulate a high level of heavy metals (up to 200mg/kg) in the root and shoot of the treated plants. If it is treated above this, then seeds were also affected and not safe for human consumption.

show abstract

“…Hexavalent chromium (Cr(VI)) is a common heavy metal contaminant in aquatic environments; it has been listed as one of the 20 toxic pollutants on the superfund priority list of hazardous substances owing to its high toxicity to humans, animals, and the ecosystem. 1,2 However, Cr(III) is an essential element used by many organisms and can be readily separated by precipitation. 3 Therefore, the reduction of Cr(VI) to less toxic Cr(III) has been recognized as an important treatment strategy.…”

Section: Introductionmentioning

confidence: 99%