Hexane soluble extract of Mallotus philippensis(Lam.) Muell. Arg. root possesses anti-leukaemic activity

Phytochemicals present in plants are a major source of imparting different medicinal properties to the plant. Four medicinal plants, i.e., Ziziphus jujube Mill., Fagonia arabica L., Mallotus phillipensis (Lam.) Müll.-Arg. and Hemidesmus indicus (L.) Schult were evaluated for their antibacterial and antioxidant potentials. Chemical analysis of ethanol and ethyl acetate extract of these plants revealed the presence of various phytochemicals in them. Antibacterial activity of extracts was measured against a Bacillus and a Pseudomonas spp. Among all of the extracts, M. phillipensis ethyl acetate extract gave maximum zone of inhibition (14mm) against Bacillus spp. Minimum inhibitory concentration of M. phillipensis ethyl acetate extract was 62.5mg/L. M. phillipensis extract was found to exhibit the maximum bacterial efflux pump inhibition potential (155%). Due to these antibacterial properties, twelve components of M. phillipensis were separated by TLC. Out of these 12, the component showing antibacterial potential was subjected to GCMS analysis which indicated that phthalic acid was the bioactive component responsible for this activity. Antioxidant potential of all extracts was also estimated by various assays where M. phillipensis had maximum potential among all. In conclusion, M. phillipensis extract had maximum antibacterial and antioxidant potential. The bioactive components isolated from this plant can further be used in pharmaceutical industries.

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“…Presence of this component in M. phillipensis plant has also been reported by other researchers [36].…”

Section: Discussionsupporting

confidence: 85%

Antibacterial and Antioxidant Potential of Ziziphus jujube, Fagonia Arabica, Mallotus phillipensis and Hemidesmus Indicus

Dilshad

Batool

2022

JJPS

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“…Hexane fraction showed promising toxicity against p53-deficient HL-60 cells (IC 50 1.5 mg dry roots equivalent/mL medium) after 72 h and, interestingly, inhibition of cell proliferation was preceded by the upregulation of the protooncogenes Cdc25A and cyclin D1 within 24 hours suggesting its antileukemic effect in HL-60 cells. After isolation and identification by GC-MS, polyphenols were the main compounds of the hexane extract that inhibited proliferation and induced apoptosis [ 49 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Mallotus philippinensisMuell. Arg (Euphorbiaceae): Ethnopharmacology and Phytochemistry Review

Gangwar

Goel

Nath

2014

BioMed Research International

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Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are known to contain different natural compounds, mainly phenols, diterpenoids, steroids, flavonoids, cardenolides, triterpenoids, coumarins, isocoumarins, and many more especially phenols; that is, bergenin, mallotophilippinens, rottlerin, and isorottlerin have been isolated, identified, and reported interesting biological activities such as antimicrobial, antioxidant, antiviral, cytotoxicity, antioxidant, anti-inflammatory, immunoregulatory activity protein inhibition against cancer cell. We have selected all the pharmacological aspects and toxicological and all its biological related studies. The present review reveals that Mallotus philippinensis is a valuable source of medicinally important natural molecules and provides convincing support for its future use in modern medicine. However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit. Further, more detailed safety data pertaining to the acute and subacute toxicity and cardio- and immunotoxicity also needs to be generated for crude extracts or its pure isolated compounds. This review underlines the interest to continue the study of this genus of the Euphorbiaceae.

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“…FlexX software is a very flexible and fast algorithm for small ligands docking in binding sites of receptors and enzymes 20 . FlexX also incorporates interactions between protein and ligand, ligand core placement, and complete ligand rebuilding 21 . The docking study is based on the hypothesis that the furanocoumarins are capable of interfering with the activities of above-mentioned target receptors and cause inhibition of their activity and cancer progression.…”

Section: Introductionmentioning

confidence: 99%

Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer

Acharya

Chacko

Bose

et al. 2019

Sci Rep

111

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Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemicals which has potent actions on ERα, PR, EGFR and mTOR inhibition. The current study is performed by the use of molecular docking as protein-ligand interactions play a vital role in drug design. The 3D structures of ERα, PR, EGFR and mTOR were obtained from the protein data bank and docked with 23 3D PubChem structures of furanocoumarin compounds using FlexX. Drug-likeness property was checked by applying the Lipinski’s rule of five on the furanocoumarins to evaluate anti-breast cancer activity. Antagonist and inhibition assay of ERα, EGFR and mTOR respectively has been performed using appropriate in-vitro techniques. The results confirm that Xanthotoxol has the best docking score for breast cancer followed by Bergapten, Angelicin, Psoralen and Isoimperatorin. Further, the in-vitro results also validate the molecular docking analysis. This study suggests that the selected furanocoumarins can be further investigated and evaluated for breast cancer treatment and management strategies.

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Hexane soluble extract of Mallotus philippensis(Lam.) Muell. Arg. root possesses anti-leukaemic activity

Cited by 8 publications

References 16 publications

Antibacterial and Antioxidant Potential of Ziziphus jujube, Fagonia Arabica, Mallotus phillipensis and Hemidesmus Indicus

Antibacterial and Antioxidant Potential of Ziziphus jujube, Fagonia Arabica, Mallotus phillipensis and Hemidesmus Indicus

Mallotus philippinensisMuell. Arg (Euphorbiaceae): Ethnopharmacology and Phytochemistry Review

Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer

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