Hexane fraction of Globimetula braunii induces mitochondria-mediated apoptosis in Plasmodium berghei-infected mice

Olanlokun, John Oludele; Ekundayo, Mercy Toluwase; Koorbanally, Neil A.; Olorunsogo, Olufunso O.

doi:10.1016/j.toxrep.2022.04.002

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…In this study, Plasmodium infection causes irreversible opening of the mitochondrial permeability transition pore in the pathological version and this could result to loss of function and cell death. We have previously provided evidences that Plasmodium infection affects mitochondrial integrity via the opening of the mitochondrial permeability transition pore opening (Olanlokun et al 2020(Olanlokun et al , 2021a(Olanlokun et al , 2021b(Olanlokun et al , 2022. Again, the opening of the mitochondrial pore will affect the mitochondrial number and thus their homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial oxidative phosphorylation and dynamics in mouse liver infected with Plasmodium berghei and the modulatory effects of a novel compound purified from Phyllanthus amarus

Olanlokun

Babarinde

Olorunsogo

2023

Preprint

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Mitochondria occupy prominent position in cell metabolism, however, infection of the host by Plasmodium species causes their dysfunction and imbalance in homeostasis. Antimalarial orthodox drugs affect oxidative phosphorylation and mitochondrial dynamics in the host cell. In this study, we observed the influence of 1, 3, 16 trimethoxy-10 methyl-17-(pent-3-enyl)cyclopenta[α]phenanthrene (TMCP) purified from Phyllanthus amarus on oxidative phosphorylation and mitochondrial dynamics in Plasmodium berghei-infected mice by assessing the extent of mRNA of mitochondrial complexes and proteins responsible for mitochondrial biogenesis, fission and fusion. P. berghei decreases the expressions of complexes I to V while TMCPT at both doses (5 and 10 mg/kg) increased them. The PGC-1α, prohibitins 1 and 2 that P. berghei infection decreased in the infected control was increased significantly by TMCP (5 mg/kg). Increase in DRP-1 mediates mitochondrial fission in the infected mice treated with TMCP while significant expressions of OPA1 and mitofusin1 in mice treated with TMCP (5 mg/kg) elicit significant mitochondrial fusion. The TMCP (5 mg/kg) initiated PINK 1-dependent mitophagy while maximum FUNDC1 expression signified full modulation of hypoxia-induced autophagy. Furthermore, TMCP initiated up-regulation of prohibitins 1 and 2 relative to the infected control. The results obtained in this study indicates that TMCP prevents bioenergetic stress and modulate mitochondrial dynamics for effective mitophagy.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial oxidative phosphorylation and dynamics in mouse liver infected with Plasmodium berghei and the modulatory effects of a novel compound purified from Phyllanthus amarus

Olanlokun

Babarinde

Olorunsogo

2023

Preprint

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“…BCl‐2 is recognized as an inhibitor of apoptosis and could halt cytochrome C function in mitochondrial, while apoptosis activators such as BAX (BCL2 Associated X) enhance the secretion of cytochrome C (Mazumdar et al, 2012; Olanlokun et al, 2022). In addition, the interaction between FAS and FAS‐ligands might mediate apoptotic death of heart cells under specific pathophysiological conditions (Tanoorsaz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti‐apoptotic process

Heydarnia

Taghian

Dehkordi

et al. 2022

Journal of Food Biochemistry

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The apoptosis process could impose significantly by hyperglycemia. According to in silico language processing and high throughput raw data analysis, we recognized hub molecular mechanisms involved in the pathogenesis of diabetic hearts and suggested a new pharmaceutical approach for declining myocardial programed cell death. Fifty male Sprague-Dawley rats were classified into five groups: healthy rats as control, diabetic rats, diabetic combined resistance/endurance training, diabetic rats which How to cite this article: Heydarnia, E., Taghian, F., Jalali Dehkordi, K., & Moghadasi, M. (2022). Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process.

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Mechanism of antimalarial action and mitigation of infection-mediated mitochondrial dysfunction by phyto-constituents of Andrographis paniculata ((Burm f.) Wall. ex Nees) in Plasmodium berghei-infected mice

Olanlokun,

Owolabi,

Odedeyi

et al. 2024

Journal of Ethnopharmacology

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Hexane fraction of Globimetula braunii induces mitochondria-mediated apoptosis in Plasmodium berghei-infected mice

Cited by 3 publications

References 39 publications

Mitochondrial oxidative phosphorylation and dynamics in mouse liver infected with Plasmodium berghei and the modulatory effects of a novel compound purified from Phyllanthus amarus

Mitochondrial oxidative phosphorylation and dynamics in mouse liver infected with Plasmodium berghei and the modulatory effects of a novel compound purified from Phyllanthus amarus

Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti‐apoptotic process

Mechanism of antimalarial action and mitigation of infection-mediated mitochondrial dysfunction by phyto-constituents of Andrographis paniculata ((Burm f.) Wall. ex Nees) in Plasmodium berghei-infected mice

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