Hexamodal Imaging with Porphyrin‐Phospholipid‐Coated Upconversion Nanoparticles

Rieffel, James; Chen, Feng; Chen, Guanying; Shao, Wei; Shao, Shuai; Chitgupi, Upendra; Hernandez, Reinier; Graves, Stephen A.; Nickles, Robert J.; Prasad, Paras N.; Kim, Chulhong; Cai, Weibo; Lovell, Jonathan F.

doi:10.1002/adma.201404739

Cited by 192 publications

(132 citation statements)

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“…The two active imaging components of PoP and UCNPs could be used in no less than six different imaging techniques, including fluorescence (FL), photoacoustic, Cerenkov luminescence (CL), PET, CT and UCL imaging ( Figure 12 ). 25 In these unique UCNPs, photoacoustic and FL could provide information on the level of particles. CT and PET have the imaging ability to visualize deep tissues.…”

Section: Applications Of Upconversion Nanostructuresmentioning

confidence: 99%

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

2016

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Along with the development of science and technology, lanthanide‐doped upconversion nanostructures as a new type of materials have taken their place in the field of nanomaterials. Upconversion luminescence is a nonlinear optical phenomenon, which absorbs two or more photons and emits one photon. Compared with traditional luminescence materials, upconversion nanostructures have many advantages, such as weak background interference, long lifetime, low excitation energy, and strong tissue penetration. These interesting nanostructures can be applied in anticounterfeit, solar cell, detection, bioimaging, therapy, and so on. This review is focused on the current advances in lanthanide‐doped upconversion nanostructures, covering not only basic luminescence mechanism, synthesis, and modification methods but also the design and fabrication of upconversion nanostructures, like core–shell nanoparticles or nanocomposites. At last, this review emphasizes the application of upconversion nanostructure in detection and bioimaging and therapy. Learning more about the advances of upconversion nanostructures can help us better exploit their excellent performance and use them in practice.

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Section: Applications Of Upconversion Nanostructuresmentioning

confidence: 99%

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

2016

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“…Strong fluorescence of porphyrin also can be used as imaging probe to monitor the pharmacokinetics. 37 Very recently, trismethylpyridylporphyrin-C 70 (PC 70 ) dyad has been reported to act as a promising photosensitizer for its reasonable water dispersibility, high photostability and favorable biocompatibility. 38 Significantly, the present PC 70 exhibits extraordinary PDT efficiency in vitro even under low-oxygen conditions due to its extremely long lifetime triplet state (211.3 μs).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the involved UCNPs may reduce the effect by energy transfer from UCNPs to porphyrin, 38 and recover part of the quenched fluorescence of porphyrin. 37 Herein, we design a multifunctional theranostic nanoplatform based on UCNPs/PC 70 nanocomposite for NIR-triggered fluorescence/UCL/ MR trimodal imaging and simultaneous PDT both in vitro and in vivo (Figure 1). To match the UV-to-blue absorption of PC 70 for high efficiency of PDT, β-NaGdF 4 :Yb,Tm@NaGdF 4 core/shell nanoparticles were rationally designed.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

Guan

Dong

et al. 2015

NPG Asia Mater

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Photodynamic therapy (PDT) is an excellent therapeutic modality for various malignant and nonmalignant cancers. This approach utilizes reactive oxygen species generated through the reaction between photosensitizer and oxygen in tissues upon light irradiation to achieve effective treatment. However, limited penetration depth and oxygen-deficient microenvironment hinder the efficiency of PDT. In this work, we design a multifunctional near-infrared (NIR)-triggered theranostic agent based on upconversion-nanoparticles-Polyoxyethylene bis (amine)-trismethylpyridylporphyrin-fullerene nanocomposite (UCNP-PEG-FA/ PC 70 ) for imaging (fluorescence/upconversion luminescence/magnetic resonance imaging)-guided photodynamic therapy. In this multimodal nanocompsite, UCNPs are employed as light transducers to convert NIR light into ultraviolet-visible light to activate PC 70 to generate singlet oxygen ( 1 O 2 ) even under low-oxygen conditions. Meanwhile, the upconversion emission, magnetic resonance imaging and fluorescence signal coming from UCNPs and PC 70 nanocomposite enable UCNP-PEG-FA/PC 70 to act as a multimodal imaging diagnostic agent, which facilitates the imaging-guided PDT. Furthermore, folate-mediated active targeting would enhance the accumulation of multifunctional hybrid in tumor. In vitro as well as in vivo results suggest that this smart nanocomposite is promising as an NIR light-triggered and -targeted theranostic platform for imaging-guided PDT of cancer, which may provide a solution to the bottleneck problems of PDT, namely, limited penetration depth and oxygen-deficient microenvironment.

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“…In addition, PET contrast has been introduced into tri-modal luminescent probes [151,152]. Recently, Rieffel et al developed a novel multimodal hyper-integrated nanoprobe by coating 64 Cu-labeled NaYbF 4 :Tm@ NaYF 4 Ln-UCNPs with biocompatible porphyrin-phospholipids (PoP) [153]. OI contrast is provided by the NIR upconversion emission of the Tm 3+ ions and the fluorescence of PoP.…”

Section: Multimodal Imagingmentioning

confidence: 99%