Hexamethyldisilane

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research Spotlight HexamethyldisilaneCompiled by Audrey Giros Audrey Giros was born in 1984 in Conflans Ste Honorine, France. She graduated from the National Polytechnic School of Chemical Engineering and Technology of Toulouse in 2009 and received in the same year her M.Sc. degree in organic chemistry. She is currently working under the supervision of Dr. Luis Blanco and Dr. Sandrine Deloisy. Her Ph.D. research project focuses on organosilicon chemistry for the total synthesis of a sila-analogue of testosterone. She is developing methodologies for the synthesis of a siliconsilicon bond-containing molecules and their use in various reactions such as functionalization or cyclization.

An Unusual and Diastereoselective Rearrangement during an Intramolecular Ene Reaction Involving a Disilane

“…In the course of our work on the synthesis of organosilicon cyclic compounds, we focused our attention on the preparation of a 1‐trimethylsilyl‐2‐methylidene‐1‐silacyclohexanol derivative by intramolecular ene reaction from a 1‐isopropenyl‐1‐(3‐oxopropyl)disilane (Scheme ; R 1 = SiMe 3 , R 2 = Me, R 3 = R 4 = H). The expected cyclic compound was envisioned as a starting material to build more elaborate scaffolds after cleavage of the silicon–silicon bond 1. Such a carbonyl ene reaction was reported by Robertson et al for isopropenyl(3‐oxopropyl)silanes.…”