Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells

Srimuangwong, Khanitta; Tocharus, Chainarong; Yoysungnoen, Bhornprom; Suksamrarn, Apichart; Tocharus, Jiraporn

doi:10.3748/wjg.v18.i19.2383

Cited by 47 publications

(30 citation statements)

References 27 publications

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“…The neoplasm-reducing effects were accompanied by a reduction in COX-2 expression, but not COX-1 expression, as well as induction of apoptosis in the epithelial cells in the focal crypts, which are usually resistant to apoptosis. In vitro studies in HT-29 cells corroborated that hexahydrocurcumin reduces cell viability and causes a decrease in COX-2 mRNA and protein levels (Srimuangwong et al, 2012b). A reduction in mRNA expression and activity of iNOS was also observed in lipopolysaccharide-stimulated RAW 264.7 macrophages incubated with hexahydrocurcumin, which was associated with a decreased activity of NF-kB and IKK1 (Pan et al, 2000).…”

Section: Tablementioning

confidence: 50%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: Tablementioning

confidence: 50%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…In a study, HHC has shown to exhibit anti-inflammatory activity by inhibiting COX-2 expression, which was comparatively lesser than curcumin [15] and antioxidant activity in murine macrophages [16]. HHC has shown to induce cytotoxicity by a massive accumulation of SW480 cells in the G1/G0 phase of the cell cycle [17] and synergistically inhibit the growth of HT-29 colorectal cancer cells with 5-fluorouracil [18].…”

Section: Figurementioning

confidence: 99%

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

2014

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Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin. One of the major metabolites of curcumin is tetrahydrocurcumin (THC), which lacks α,β-unsaturated carbonyl moiety and is white in color. Whether THC is superior to curcumin on a molecular level is unclear and thus is the focus of this review. Various studies suggest that curcumin is a more potent antioxidant than THC; curcumin (but not THC) can bind and inhibit numerous targets including DNA (cytosine-5)-methyltransferase-1, heme oxygenase-1, Nrf2, β-catenin, cyclooxygenase-2, NF-kappaB, inducible nitric oxide synthase, nitric oxide, amyloid plaques, reactive oxygen species, vascular endothelial growth factor, cyclin D1, glutathione, P300/CBP, 5-lipoxygenase, cytosolic phospholipase A2, prostaglandin E2, inhibitor of NF-kappaB kinase-1, -2, P38MAPK, p-Tau, tumor necrosis factor-α, forkhead box O3a, CRAC; curcumin can inhibit tumor cell growth and suppress cellular entry of viruses such as influenza A virus and hepatitis C virus much more effectively than THC; curcumin affects membrane mobility; and curcumin is also more effective than THC in suppressing phorbol-ester-induced tumor promotion. Other OPEN ACCESSMolecules 2015, 20 186 studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. Most studies have indicated that THC exhibits higher antioxidant activity, but curcumin exhibits both pro-oxidant and antioxidant properties.

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“…Both phytochemicals are found in Mirabilis japala roots and leaves which are used for treatment tonsillitis, cystysis, and leucorrhoea (Butera et al, 2002;Tesoriere et al, 2005;. A cytotoxic effect against colorectal cancer is detected in Hexahydrocurcumin which is found in Zingiber officinale (Srimuangwong et al, 2012;. A study has reported that Zingiber officinale extracts indicate biological effects such as immunomodulator, antitumor, antiinflammation, anti-apoptosis, anti-hyperglycemia, anti-lipidemia and anti-emetics (Ali et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Indicaxanthin, Miraxanthin-V, and Hexahydrocurcumin as Potential Erythropoietin Agonist in Silico to Treat Anemia in Chronic Kidney Disease

Suselo¹,

Kamil²,

Wulandari³

et al. 2017

Proceedings of the Health Science International Conference (HSIC 2017)

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Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells

Abstract: HHC together with 5-FU exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer.

Cited by 47 publications

References 27 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

Indicaxanthin, Miraxanthin-V, and Hexahydrocurcumin as Potential Erythropoietin Agonist in Silico to Treat Anemia in Chronic Kidney Disease

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