Hexagonal boron nitrides reduce the oxidative stress on cells

Taşkin, Irem Çulha; Şen, Özlem; Emanet, Melis; Çulha, Mustafa; Yılmaz, Bayram

doi:10.1088/1361-6528/ab6fdc

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…Two-dimensional hexagonal boron nitride (h-BN) connected by strong sp 2 covalent bonding, an isomorph of graphene with similar lattice parameters [ 98 ], is receiving great attention in future electronic devices due to excellent mechanical properties [ 99 , 100 ], chemical stability [ 101 , 102 ] and optical properties [ 103 ]. Similar to other 2D materials, the layered structure bulk h-BN can be separated into monolayer or 2D structures with a thickness of several nanometers by mechanical and chemical exfoliation [ 104 – 117 ].…”

Section: Types Of 2d Materials Applicable For Remote Epitaxymentioning

confidence: 99%

Understanding the 2D-material and substrate interaction during epitaxial growth towards successful remote epitaxy: a review

Kwak

et al. 2023

Nano Convergence

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Remote epitaxy, which was discovered and reported in 2017, has seen a surge of interest in recent years. Although the technology seemed to be difficult to reproduce by other labs at first, remote epitaxy has come a long way and many groups are able to consistently reproduce the results with a wide range of material systems including III-V, III-N, wide band-gap semiconductors, complex-oxides, and even elementary semiconductors such as Ge. As with any nascent technology, there are critical parameters which must be carefully studied and understood to allow wide-spread adoption of the new technology. For remote epitaxy, the critical parameters are the (1) quality of two-dimensional (2D) materials, (2) transfer or growth of 2D materials on the substrate, (3) epitaxial growth method and condition. In this review, we will give an in-depth overview of the different types of 2D materials used for remote epitaxy reported thus far, and the importance of the growth and transfer method used for the 2D materials. Then, we will introduce the various growth methods for remote epitaxy and highlight the important points in growth condition for each growth method that enables successful epitaxial growth on 2D-coated single-crystalline substrates. We hope this review will give a focused overview of the 2D-material and substrate interaction at the sample preparation stage for remote epitaxy and during growth, which have not been covered in any other review to date. Graphical Abstract

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Section: Types Of 2d Materials Applicable For Remote Epitaxymentioning

confidence: 99%

Understanding the 2D-material and substrate interaction during epitaxial growth towards successful remote epitaxy: a review

Kwak

et al. 2023

Nano Convergence

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“…Similarly, Taskin et al showed that the round-shaped BNs they used in their studies did not generate ROS at low doses. 21 Also a recent study on hBN particle with round shape showed that hBNs led to increases of TAS levels and decreases of TOS levels in Parkinson Disease model. 5 In this case, the reliability of the medical grade hBN may be related to the morphological structure.…”

Section: Discussionmentioning

confidence: 97%

Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis

et al. 2021

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Background: Hexagonal boron nitride nanoparticles (hBN NPs) are encouraging nanomaterials with unique chemical properties in medicine and biomedical fields. Until now, the optimal hBN NP’s dosage and biochemical mechanism that can be used for in vivo systems has not been fully revealed. The main aim of this article is to reveal characteristics, serum and tissue interactions and any acute cytotoxic effect of different dose of hBN NPs for the first time. Methods: hBN NPs at concentrations varying between 50–3200 µg/kg was administered by intravenous injection to Wistar albino rats (n = 80) divided into seven dosage and control groups. Blood and tissue samples were taken after 24 hours. Results: Our findings suggested that higher doses hBN NPs caused oxidative stress on the serum of rats dose-dependently. However, hBN NPs did not affect thiol/disulfide homeostasis on kidney, liver, spleen, pancreas and heart tissue of rats. Furthermore, hBN NPs increased serum disulfide formation by disrupting the thiol/disulfide balance in rats. Also, LOOH and MPO levels increased at high doses, while CAT levels decreased statistically. Conclusion: The results revealed that hBN NPs induce oxidative stress in a dose-dependent manner by modulating thiol/disulfide homeostasis in rats at higher concentrations

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“…Based on previous work on the preparation of 10 B-enriched boron nanoparticles for treating murine brain tumors via BNCT, we used the ALTS1C1 cells as a model study for a proof-of-concept demonstration [43]. Although it is well known that nanoparticle drugs cannot infiltrate the blood-brain barrier (BBB) to treat brain-related diseases, researchers have used various strategies to temporarily disrupt the BBB to allow nanotherapeutics to be delivered to the brain [92,93]. Moreover, research has demonstrated that the ALTSIC1 murine brain tumor model is highly infiltrative, making it a suitable candidate for future in vivo studies [91].…”

Section: Cytotoxicity Study Of the Bcno Pei@bcno And Peg@bcnomentioning

confidence: 99%

Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-10B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug

Chiang

Chien

et al. 2021

Nanomaterials

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Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing 10B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boron drugs for BNCT relies on the use of the costly B-10 enriched precursor. To overcome these challenges, polymer-coated boron carbon oxynitride (BCNO) nanoparticles, with ~30% of boron, were developed with enhanced biocompatibility, cell uptake, and tumoricidal effect via BNCT. Using the ALTS1C1 cancer cell line, the IC50 of the PEG@BCNO, bare, PEI@BCNO were determined to be 0.3 mg/mL, 0.1 mg/mL, and 0.05 mg/mL, respectively. As a proof-of-concept, the engineered non-10B enriched polymer-coated BCNO exhibited excellent anti-tumor effect via BNCT due to their high boron content per nanoparticle and due to the enhanced cellular internalization and retention compared to small molecular 10B-BPA drug. The astrocytoma ALTS1C1 cells treated with bare, polyethyleneimine-, and polyethylene glycol-coated BCNO exhibited an acute cell death of 24, 37, and 43%, respectively, upon 30 min of neutron irradiation compared to the negligible cell death in PBS-treated and non-irradiated cells. The radical approach proposed in this study addresses the expensive and complex issues of B-10 isotope enrichment process; thus, enabling the preparation of boron drugs at a significantly lower cost, which will facilitate the development of boron drugs for BNCT.

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Hexagonal boron nitrides reduce the oxidative stress on cells

Cited by 12 publications

References 30 publications

Understanding the 2D-material and substrate interaction during epitaxial growth towards successful remote epitaxy: a review

Understanding the 2D-material and substrate interaction during epitaxial growth towards successful remote epitaxy: a review

Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis

Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-10B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug

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