“…The current state of laser-based optical biosensors has mostly evolved around the use of laser dyes as a gain medium. − Such dye-based sensors typically result in a broad lasing spectrum (10 to 30 nm line widthwhich is comparable to fluorescence-based sensors) and are subject to degradation of the laser dye. As such, solid-state gain medium for random lasers has been extensively investigated by researchers to replace the need for laser dyes to achieve lasing. − Certain types of random lasers employing a solid-state gain medium with high scattering provided by the gain medium itself and have been shown to provide a narrow emission line. − Hence, degradation issues could be addressed by employing a solid-state gain medium with current laser-based biosensors.…”
In this review, the concept of open
cavity lasing for ultrasensitive
sensing is explored, specifically in driving important innovations
as laser-based biosensorsa field mostly dominated by fluorescence-based
sensing. Laser-based sensing exhibits higher signal amplification
and lower signal-to-noise ratio due to narrow emission lines as well
as high sensitivity due to nonlinear components. The versatility of
open cavity random lasers for probing analytes directly which is ultrasensitive
to small changes in chemical composition and temperature fluctuations
paves the path of utilizing narrow emission lines for advanced sensing.
The concept of random lasing is first explained followed by a comparison
of the different lasing threshold that has been reported. This is
followed by a survey of reports on laser-based sensing and more specifically
as biosensors. Finally, a perspective on the way forward for open
cavity laser-based sensing is put forth.
“…The current state of laser-based optical biosensors has mostly evolved around the use of laser dyes as a gain medium. − Such dye-based sensors typically result in a broad lasing spectrum (10 to 30 nm line widthwhich is comparable to fluorescence-based sensors) and are subject to degradation of the laser dye. As such, solid-state gain medium for random lasers has been extensively investigated by researchers to replace the need for laser dyes to achieve lasing. − Certain types of random lasers employing a solid-state gain medium with high scattering provided by the gain medium itself and have been shown to provide a narrow emission line. − Hence, degradation issues could be addressed by employing a solid-state gain medium with current laser-based biosensors.…”
In this review, the concept of open
cavity lasing for ultrasensitive
sensing is explored, specifically in driving important innovations
as laser-based biosensorsa field mostly dominated by fluorescence-based
sensing. Laser-based sensing exhibits higher signal amplification
and lower signal-to-noise ratio due to narrow emission lines as well
as high sensitivity due to nonlinear components. The versatility of
open cavity random lasers for probing analytes directly which is ultrasensitive
to small changes in chemical composition and temperature fluctuations
paves the path of utilizing narrow emission lines for advanced sensing.
The concept of random lasing is first explained followed by a comparison
of the different lasing threshold that has been reported. This is
followed by a survey of reports on laser-based sensing and more specifically
as biosensors. Finally, a perspective on the way forward for open
cavity laser-based sensing is put forth.
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