Hexafluorobenzene: a Sensitive 19F NMR Indicator of Tumor Oxygenation

Mason, Ralph P.; Rodbumrung, Watchara; Antich, Peter P.

doi:10.1002/(sici)1099-1492(199605)9:3<125::aid-nbm405>3.3.co;2-6

Cited by 39 publications

(67 citation statements)

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“…Symmetry provides a single narrow 19 F NMR signal and the R 1 is highly sensitive to changes in pO 2 , yet minimally responsive to temperature. 92 It is also well characterized in terms of lack of toxicity. Intratumoral injection of PFCs compared with i.v.…”

Section: Techniques For the Assessment Of Tumor Oxygenationmentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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This review paper attempts to provide an overview of the principles and techniques that are often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the potential of such methods and illustrates they have been successfully applied to measure oxygen tension, an essential parameter of the tumor microenvironment. To help the reader understand the motivation for carrying out these measurements, the importance of tumor hypoxia is first discussed: the basic issues of why a tumor is hypoxic, why these hypoxic microenvironments promote processes driving malignant progression and why hypoxia dramatically influences the response of tumors to cytotoxic treatments will be explained. The different methods that have been used to estimate the oxygenation in tumors will be reviewed. To introduce the basics of EPR oximetry, the specificity of in vivo EPR will be discussed by comparing this technique with NMR and MRI. The different types of paramagnetic oxygen sensors will be presented, as well as the methods for recording the information (EPR spectroscopy, EPR imaging, dynamic nuclear polarization). Several applications of EPR for characterizing tumor oxygenation will be illustrated, with a special emphasis on pharmacological interventions that modulate the tumor microenvironment. Finally, the challenges for transposing the method into the clinic will also be discussed.

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Section: Techniques For the Assessment Of Tumor Oxygenationmentioning

confidence: 99%

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004

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“…The relative error introduced into a pO 2 determination by a 1 C error in temperature estimate ranges from 8 Torr/ C for PFTB [207] to 3 Torr/ C for PFOB (perflubron) [223] or 15-Crown-5-ether [218] when pO 2 is actually 5 Torr. HFB exhibits remarkable lack of temperature dependence and the comparative error would be 0.1 Torr/ C [224]. Recognizing differential sensitivity of pairs of resonances within a single molecule to pO 2 and temperature, Mason et al [207,225] patented a method to simultaneously determine both parameters by solving simultaneous equations.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 97%

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

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“…[13][14][15] Measurements of local pO 2 can also be made by measuring the oxygen-sensitive T 1 relaxation rate of perfluorocarbons (PFC's). [16][17][18][19] These compounds have to be introduced, either through direct injection or by vascular infusion. 18,19 The sensitivity of the method is a limiting feature.…”

Section: Oxygen Transport To and Utilization By Tissuementioning

confidence: 99%

Tissue oxygenation in sepsis; new insights from in vivo EPR

2004

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Nitric oxide (NO) is a key mediator in the maldistribution of oxygen by tissue and organ dysfunction observed in sepsis. Despite this, few techniques are capable of measuring these parameters directly in vivo. We describe here several techniques that have been developed by our group to address this directly by in vivo EPR in animal models of sepsis. Oxygen-sensitive materials can be implanted or administered and report on local tissue pO 2 . Spin trapping of NO can simultaneously report on tissue NO content. Repeat measures of these parameters can be made directly from a defined tissue site, allowing development of new models and experiments to study the defects in tissue and organ function seen in sepsis.

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Hexafluorobenzene: a Sensitive 19F NMR Indicator of Tumor Oxygenation

Cited by 39 publications

References 0 publications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Tissue oxygenation in sepsis; new insights from in vivo EPR

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