1985
DOI: 10.1590/s0036-46651985000400006
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Abstract: SUMMARYTreatment of mouse tail skins with hexachlorophene (1.25% w/v) in abso lute methanol or 70% isopropanol suppressed Schistosoma mansoni infections by more than 95% even when the application was performed up to three days prior to exposure to cercarial suspensions by tail immersion. Treatment with concen trations of 0.313% or higher one day prior to exposure provided at least 98% protection when the treated surface was not subjected to water washes of greater duration than 1/2 hour. Tail immersion applica… Show more

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Cited by 2 publications
(2 citation statements)
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“…Among these, a few compounds such as N,N-diethyllauramide, niclosamide, Cederol (Fluka Chemicals Corp., Ronkonkoma, NY), hexachlorophene, dibutyl phthalate, and benzyl benzoate were found to have significant cercaricidal effect in vitro. [6][7][8][9] However, except for niclosamide, none of the other chemicals were tested for their clinical application under field conditions. 10 During one of our routine studies to screen an appropriate vehicle for skin application of Cederol against cercariae, we accidentally found that a commercially available insect repellent (Off; S. C. Johnson Inc., Racine, WI) was highly effective in preventing cercarial skin penetration.…”
mentioning
confidence: 99%
“…Among these, a few compounds such as N,N-diethyllauramide, niclosamide, Cederol (Fluka Chemicals Corp., Ronkonkoma, NY), hexachlorophene, dibutyl phthalate, and benzyl benzoate were found to have significant cercaricidal effect in vitro. [6][7][8][9] However, except for niclosamide, none of the other chemicals were tested for their clinical application under field conditions. 10 During one of our routine studies to screen an appropriate vehicle for skin application of Cederol against cercariae, we accidentally found that a commercially available insect repellent (Off; S. C. Johnson Inc., Racine, WI) was highly effective in preventing cercarial skin penetration.…”
mentioning
confidence: 99%
“…Therefore, blocking entry of cercariae into the skin could potentially control the infection. Over the years, several topical agents have been evaluated for their ability to block cercarial penetration into the skin [9][10][11][12][13][14][15][16][17]. Some of these compounds are highly effective, but …”
Section: Introductionmentioning
confidence: 99%