2012
DOI: 10.1111/j.1755-5949.2012.00322.x
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Heterozygote Genotypes at rs2222823 and rs2811712 SNP Loci are Associated with Cerebral Small Vessel Disease in Han Chinese Population

Abstract: The heterozygotes (T/A) at the rs2222823 SNP locus of MYLK gene decreases the risk of having cerebral small vessel disease, while the heterozygotes (C/T) at the rs2811712 SNP locus of INK4/ARF gene increases the risk, suggesting that the MYLK and INK4/ARF are the associated genes of cerebral small vessel disease in Han Chinese population.

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Cited by 16 publications
(12 citation statements)
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“…6,8 AQP4 gene, therefore, has a strong biological rationale for involvement in brain edema formation after TBI and consequently in the clinical outcome of patients with TBI. Despite the considerable efforts made in recent years to identify any possible associations between AQP4 gene polymorphisms and various diseases including inflammatory demyelinating disease (multiple sclerosis and neuromyelitis optica), 28,29 idiopathic intracranial hypertension, 30 cerebral small vessel disease, 31 and migraine, 32 there has been little success in identifying regions of AQP4 gene with functional significance. [33][34][35] A previous study in patients with TBI, examining possible involvement of coding variants in AQP4 exon 4, failed to demonstrate any significant influence on outcome of patients with TBI, because no coding polymorphisms in exon 4 of AQP4 gene were detected.…”
Section: Discussionmentioning
confidence: 99%
“…6,8 AQP4 gene, therefore, has a strong biological rationale for involvement in brain edema formation after TBI and consequently in the clinical outcome of patients with TBI. Despite the considerable efforts made in recent years to identify any possible associations between AQP4 gene polymorphisms and various diseases including inflammatory demyelinating disease (multiple sclerosis and neuromyelitis optica), 28,29 idiopathic intracranial hypertension, 30 cerebral small vessel disease, 31 and migraine, 32 there has been little success in identifying regions of AQP4 gene with functional significance. [33][34][35] A previous study in patients with TBI, examining possible involvement of coding variants in AQP4 exon 4, failed to demonstrate any significant influence on outcome of patients with TBI, because no coding polymorphisms in exon 4 of AQP4 gene were detected.…”
Section: Discussionmentioning
confidence: 99%
“…Extracted genomic DNA samples were stored at −80°C until genotyping was performed. The variants for rs2208454 were genotyped using the snapshot method described previously . For polymerase chain reaction (PCR), the forward primer sequence was GCCAGATTAGATCTGAGCTAGGGTGT.…”
Section: Methodsmentioning
confidence: 99%
“…Then needle was taken out, and incision was stitched. The signs, which showed rabbit cerebral hemorrhage model was successful, were [11][12][13] as follows: (1) After blood injection, there was right side limb weakness and hemiplegia, head tilted to the right side; (2) After recovering from anesthesia, there was obvious right limb claudication while walking.…”
Section: Establishment Of Cerebral Hemorrhage Animal Modelmentioning
confidence: 99%