Heterozygosity for the rs696217 SNP in the Preproghrelin Gene Predicts Weight Loss After Bariatric Surgery in Severely Obese Individuals

Vitolo, Edoardo; Santini, Eleonora; Seghieri, Marta; Giannini, Livia; Coppedè, Fabio; Rossi, Chiara; Dardano, Angela; Solini, Anna

doi:10.1007/s11695-016-2387-6

Cited by 20 publications

(17 citation statements)

References 35 publications

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“…Table 4 summarizes studies identifying characteristics associated with weight loss response to MBS. A majority of these studies involve Roux-en-Y gastric bypass (RYGB), [100][101][102][103][104][105][106][107][108][109][110][111][112][113] with a few evaluating vertical sleeve gastrectomy (VSG), 114 laparoscopic adjustable gastric banding (LAGB), [115][116][117] biliopancreatic diversion (BPD), 118 sleeve gastroplasty, 119 or a pooling of data from multiple procedures. [120][121][122][123][124] Overall, studies exploring predictors of weight loss response to MBS in adolescents are rare.…”

Section: Metabolic and Bariatric Surgerymentioning

confidence: 99%

Precision medicine in adult and pediatric obesity: a clinical perspective

Bomberg

Ryder

Brundage

et al. 2019

Therapeutic Advances in Endocrinology

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It remains largely unknown as to why some individuals experience substantial weight loss with obesity interventions, while others receiving these same interventions do not. Person-specific characteristics likely play a significant role in this heterogeneity in treatment response. The practice of precision medicine accounts for an individual’s genes, environment, and lifestyle when deciding upon treatment type and intensity in order to optimize benefit and minimize risk. In this review, we first discuss biopsychosocial determinants of obesity, as understanding the complexity of this disease is necessary for appreciating how difficult it is to develop individualized treatment plans. Next, we present literature on person-specific characteristics associated with, and predictive of, weight loss response to various obesity treatments including lifestyle modification, pharmacotherapy, metabolic and bariatric surgery, and medical devices. Finally, we discuss important gaps in our understanding of the causes of obesity in relation to the suboptimal treatment outcomes in certain patients, and offer solutions that may lead to the development of more effective and targeted obesity therapies.

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Section: Metabolic and Bariatric Surgerymentioning

confidence: 99%

Precision medicine in adult and pediatric obesity: a clinical perspective

Bomberg

Ryder

Brundage

et al. 2019

Therapeutic Advances in Endocrinology

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“…Ghrelin is expressed by GHRL gene, several SNP are informed for it. In literature is actively studied the SNP allele polymorphism with obesity [10,11], food behavior disorders [12] and metabolism disturbances [13], and also with gastric acid secretion [14] and fast stomach emptying [15,16]. Mutations in this gene can cause low levels of ghrelin, registered at obesity [17].…”

Section: Introductionmentioning

confidence: 99%

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

Dats-Opoka

Makukh

Hnateyko

2017

EUREKA: Health Sciences

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Gastroesophageal disease (GERD) is the one of most spread diseases that injures an esophagus. Taking into account the large number of factors that can cause GERD development already in child age, including genetic predisposition, it is necessary to analyze each of them in detail. Aim of this work was to analyze a frequency and possible association type of р. Leu72Met mutation of GHRL gene in children with gastroesophageal reflux disease. The analysis of clinical parameters and course of disease in the group of 100 schoolchildren with GERD was carried out. The molecular-genetic study of c.214C>A locus of GHRL gene by CPR method (rs696217) was carried out in patients with GERD and 40 healthy children from the control group. In 82% of children with GERD was revealed a GHRL 214СС (Leu/Leu) homozygous genotype, at 58% among children from the control group. GHRL 214СА (Leu/ Met) genotype was registered three times more seldom in children of the studied group comparing with ones from the control group: 15,0% and 42,5%, respectively. It was established, that GHRL 214CС genotype presence conditions the increase of GERD development risk in 3,4 times. On the contrary, GHRL 214CА genotype manifests a reliable protective effect that is essentially decreased GERD development risk in a child at such genotype – 0,24 comparing with a conventional unit. There was established alleles and genotypes distribution of c.214C>A (р.Leu72Met) locus of GHRL gene in children with GERD. GHRL 214CС genotype is associated with threefold increase of GERD risk development. Gender differences as to GERD development risk at different genotypes of ghrelin gene were established. At GHRL 214СС (Leu/Leu) genotype the relative GERD risk for boys increased in more than 6 times. There were not established any differences in alleles and genotypes distribution depending on erosive or surface inflammatory changes of a gastrointestinal tract mucosa.

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“…When Seip et al (2016) [ 26 ] evaluated 330 SNPs of genes involved in metabolic regulation they identified many genes that could be potential markers to discriminate changes in body mass index (BMI) one year after surgical intervention (LAGB or RYGB). Other authors suggested that polymorphisms, like the SNP of the preproghrelin gene (rs696217), could mark a successful weight loss outcome [ 27 ]. Table 1 lists recent studies that associate SNPs and bariatric surgery outcomes.…”

Section: Genetic Background and Bariatric Surgery Managementmentioning

confidence: 99%

Bariatric Surgery and Precision Nutrition

et al. 2017

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This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of nutritional genomics: nutrigenetics, nutrigenomics, and epigenetics. We present studies that show the effect of each patient’s genetic and epigenetic variables on the response to surgical weight loss treatment. We include investigations that demonstrate the association of single nucleotide polymorphisms with obesity phenotypes and their influence on weight loss after bariatric surgery. We also present reports on how significant weight loss induced by bariatric surgery impacts telomere length, and we discuss studies on the existence of an epigenetic signature associated with surgery outcomes and specific gene methylation profile, which may help to predict weight loss after a surgical procedure. Finally, we show articles which evidence that bariatric surgery may affect expression of numerous genes involved in different metabolic pathways and consequently induce functional and taxonomic changes in gut microbial communities. The role nutritional genomics plays in responses to weight loss after bariatric surgery is evident. Better understanding of the molecular pathways involved in this process is necessary for successful weight management and maintenance.

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Heterozygosity for the rs696217 SNP in the Preproghrelin Gene Predicts Weight Loss After Bariatric Surgery in Severely Obese Individuals

Abstract: Carrying a G to T substitution in rs696217 (preproghrelin gene) seems to mark a successful weight loss outcome; we also report for the first time that the rs1126535 C allele (CD40L gene) may predict a worse response to bariatric surgery.

Cited by 20 publications

References 35 publications

Precision medicine in adult and pediatric obesity: a clinical perspective

Precision medicine in adult and pediatric obesity: a clinical perspective

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

Bariatric Surgery and Precision Nutrition

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