Heterotransplantation of Tumors into Various Regions of the Guinea-Pig Eye*

Extraocular Seeding of Choroidal Melanoma After a Transretinal Biopsy With a 25-Gauge Vitrector

“…Clinical experience and animal experiments indicate that recurrent tumors at entry sites rarely develop even if seeding of tumor cells does occur. 7,8 It is beyond the scope of this case report to discuss whether intraocular tumor biopsy with the 25-gauge vitrectomy system is superior to fine-needle aspiration biopsy, which in other centers have proved perfectly adequate. 9 There is a growing impression that even if such local seeding takes place, it is unlikely to influence survival because uveal melanomas with a metastatic potential have already disseminated systemically by the time the patient first presents to an ophthalmologist.…”

Intraocular biopsy of uveal melanoma Risk assessment and identification of genetic prognostic markers

“…), but the clinical significance of seeded tumour cells in the vitreous body is doubtful. We know from animal studies that tumour cells do not grow well in the avascular vitreous (Snell ). Furthermore, spontaneous migration of tumour cells into the vitreous body in treatment naïve patient eyes does not seem to be associated with bad prognosis (Metz et al.…”

Epibulbar Seeding at the Site of a Transvitreal Fine-Needle Aspiration Biopsy

“…The few malignant cells along the needle track seem to disappear spontaneously and could be insufficient for tumor growth. 9 In addition, experimental animal studies have shown the difficulty in transplanting tumor cells in vitreous, 10 and most of the malignant ocular tumors are treated by irradiation or excision after diagnosis, which probably prevents implantation of metastasis in most cases.…”