Cornual heterotopic pregnancy is an extremely rare, life-threatening complication during pregnancy. Here, we report on a 33-year-old woman who suffered cornual heterotopic pregnancy after in vitro fertilization embryo transfer. To prevent rupture during heterotopic pregnancy, she received laparoscopic surgery to remove the ectopic gestational sac at 7 +2 weeks of gestation. Ultimately, she delivered a healthy boy at 38 +3 weeks of gestation. Here, we also review the clinical presentations, risk factors, treatment options and outcomes of cornual heterotopic pregnancy.Heterotopic pregnancy (HP) is a pathological pregnancy in which one or more viable embryos implant in the uterus and outside the uterine cavity. [1] Up to 98% of ectopic gestations are located in the fallopian tube. [2] The incidence of HP is approximately between 1/3900 to 1/30 000 in natural pregnancies. [3,4] Cornual heterotopic pregnancy (CHP), where the embryo implants in the lateral angle of the uterine cavity close to the internal ostium of the fallopian tube, is a rare event. [5] With increases in infertility and the wide use of assisted reproduction techniques (ART), the risk of CHP has increased to 1%-3% in some regions. [4,6] Women who have a history of