Heterotopic Ossification

Rush, Beth

doi:10.1007/978-3-319-56782-2_244-2

Cited by 1 publication

(1 citation statement)

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“…Heterotopic ossification (HO), also known as heterotopic bone formation, is the process of benign bone formation and growth outside of normal skeletal locations (Sullivan et al, 2013). Neurogenic heterotopic ossification (NHO) was first described at the end of the nineteenth century and was predominantly observed among soldiers who had experienced spinal cord trauma during combat in World War I (Shehab, Elgazzar & Collier, 2002). At present, three subtypes of NHO have been described: traumatic, neurologic, and genetic.…”

Section: Introductionmentioning

confidence: 99%

Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining

Zhang

Zhan

Kou

et al. 2020

PeerJ

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Background Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury (SCI-TBI-HO). However, the underlying mechanisms of SCI-TBI-HO have proven difficult to elucidate. The aim of the present study is to identify the most promising candidate genes and biological pathways for SCI-TBI-HO. Methods In this study, we used text mining to generate potential explanations for SCI-TBI-HO. Moreover, we employed several additional datasets, including gene expression profile data, drug data and tissue-specific gene expression data, to explore promising genes that associated with SCI-TBI-HO. Results We identified four SCI-TBI-HO-associated genes, including GDF15, LDLR, CCL2, and CLU. Finally, using enrichment analysis, we identified several pathways, including integrin signaling, insulin pathway, internalization of ErbB1, urokinase-type plasminogen activator and uPAR-mediated signaling, PDGFR-beta signaling pathway, EGF receptor (ErbB1) signaling pathway, and class I PI3K signaling events, which may be associated with SCI-TBI-HO. Conclusions These results enhance our understanding of the molecular mechanisms of SCI-TBI-HO and offer new leads for researchers and innovative therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%