Heterotopic gastric mucosa in the gallbladder

Abstract

We report on a case of heterotopic gastric mucosa in the body of the gallbladder. A 39-year-old man, who was asymptomatic, visited our hospital because of a polypoid lesion in the gallbladder, discovered during a routine health screening. Ultrasonography (US) revealed a broad-based polypoid lesion 1.7 cm in diameter in the body of the gallbladder, which was free of gallstones. The gallbladder mass was faintly enhanced by helical computed tomography. Laparoscopic cholecystectomy was performed because of the possibility of malignancy. The specimen revealed a 1.7 x 1.3 cm polypoid lesion with deep delle in the body, with no gallstones in the gallbladder. Intraoperative frozen examination yielded a diagnosis of hyperplastic polyp of the gallbladder. Histologically, the polypoid lesion consisted of gastric fundic glands located in the whole wall of the gallbladder. The surrounding mucosa consisted of almost normal epithelium without any metaplastic changes. Postoperative technetium 99m-pertechnetate scintigraphy demonstrated no evidence of gastric heterotopia elsewhere in the body. We also review 18 other reports of heterotopic gastric mucosa in the gallbladder in the Japanese medical literature.

Heterotopic gastric mucosa in the gallbladder: Report of two cases

“…3 The fi rst case of heterotopic gastric mucosa in the gallbladder was described in 1934 by Egyedi. 4 In Japan, 25 cases have so far been reported, including that in the present patients since the fi rst case reported by Tomita in 1977, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] while 51 cases of heterotopic gastric mucosa in the gallbladder had been reported in other countries up to 2007. 1,3,[21][22][23][24][25][26][27][28][29] In the 72 detailed case reports (including our own), the sex distribution is roughly equal (40 males, 32 females).…”

“…Seventeen cases presented with an echogenic polypoid lesion in the gallbladder as in our two cases, 1,6,9,10,15,[17][18][19][20]24,26,28 whereas a low echogenic polypoid lesion was diagnosed in three cases. 3,11,13 In addition, one case presented with a thickwalled gallbladder.…”

A mimicker of gallbladder carcinoma: cystic gastric heterotopia with intestinal metaplasia

“…The presence of heterotopic gastric mucosa in gallbladder first described in 1934 (5), although widely described in the literature, it still appears to be a very rare condition in The lesion is often discovered incidentally, but when symptoms are reported, nausea, vomiting, and upper quadrant abdominal pain seem to be the most common symptoms (7). Heterotopic gastric mucosa is either incidentally found in the gallbladder that has undergone cholecystectomy due to cholelithiasis or cholecystitis, or recognized as a polypoid lesion at abdominal ultrasonography (8).…”

Pyloric gland type adenoma including intramucosal carcinoma focus of gallbladder

“…In the literature, we determined 23 cases of HGM of (5). We also determined three other publications which 4 cases of HGM were analyzed in these reports (6)(7)(8).…”

“…Fundic glands are not seen. (5)(6)(7)(8). MEC may be congenital or secondary to cholecystitis, cholelithiasis, or a tumoral growing (8).…”