Heterotopic bone formation following hip arthroplasty: A retrospective study of 65 bilateral cases

Kjægaard-Andersen, Per; Steinke, Martin Søe; Hougaard, Kjeld; Søjbjerg, Jens Ole; Jensen, John

doi:10.3109/17453679108993596

Cited by 10 publications

(5 citation statements)

References 15 publications

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“…The principal reasons for the exclusion of studies were the absence of information about the incidence of heterotopic bone formation or about the number of participants or hips, 7,14 , 227−279 the conduct of other surgical procedures (e.g. cup arthroplasty, repair of hip fracture or resection of heterotopic bone formation), 2,216,280−298 repeat publication of data included in another report, 60,65,299−339 review articles with no original data, 1,3−6,8,12,340−363 data restricted to heterotopic bone formation at non‐hip sites, 11,364−381 and data restricted to heterotopic bone formation in non‐human species 382−388 . The reports from a number of other possibly relevant studies were not available for review 82,389−421 …”

Section: Resultsmentioning

confidence: 99%

Incidence of heterotopic bone formation after major hip surgery

Neal

Gray

MacMahon

et al. 2002

ANZ Journal of Surgery

125

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Section: Resultsmentioning

confidence: 99%

Incidence of heterotopic bone formation after major hip surgery

Neal

Gray

MacMahon

et al. 2002

ANZ Journal of Surgery

125

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“…Female wild-type mice formed significantly more BMP6-induced HO than male mice (Figure 6A), showing that the observed female-dominant sex difference in HO volumes is not restricted to FOP mice. We note that sex differences have been reported in non-FOP models of HO and in patients who experience non-FOP HO induced by various insults and disease states [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In these contexts, however, the sex difference is typically male-dominant.…”

Section: Biological Sex Impacts On Bmp-induced Ho and The Effect Of A...mentioning

confidence: 69%

“…Specifically, numerous clinical studies of non-genetic HO have reported male sex as a risk factor. Males exhibit both a higher incidence of HO and a more robust HO response after procedures such as cervical disk replacement/arthroplasty [6][7][8], hip arthroplasty [9,10], femoral intramedullary rodding [11], and injuries that include traumatic brain injury [12] and burns [13]. HO was observed exclusively in males following rhBMP7 treatment of long bone non-unions [14].…”

Section: Introductionmentioning

confidence: 99%

Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva

Burdick,

DelVichio,

Hanson

et al. 2024

Biomolecules

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Heterotopic ossification (HO) is most dramatically manifested in the rare and severely debilitating disease, fibrodysplasia ossificans progressiva (FOP), in which heterotopic bone progressively accumulates in skeletal muscles and associated soft tissues. The great majority of FOP cases are caused by a single amino acid substitution in the type 1 bone morphogenetic protein (BMP) receptor ACVR1, a mutation that imparts responsiveness to activin A. Although it is well-established that biological sex is a critical variable in a range of physiological and disease processes, the impact of sex on HO in animal models of FOP has not been explored. We show that female FOP mice exhibit both significantly greater and more variable HO responses after muscle injury. Additionally, the incidence of spontaneous HO was significantly greater in female mice. This sex dimorphism is not dependent on gonadally derived sex hormones, and reciprocal cell transplantations indicate that apparent differences in osteogenic activity are intrinsic to the sex of the transplanted cells. By circumventing the absolute requirement for activin A using an agonist of mutant ACVR1, we show that the female-specific response to muscle injury or BMP2 implantation is dependent on activin A. These data identify sex as a critical variable in basic and pre-clinical studies of FOP.

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“…35,50 Clinical studies have shown that the NSAID indomethacin reduces heterotopic ossification in patients undergoing hip arthroplasty. 2,15,21,26,28,29,[38][39][40]44 This effect was also reported to occur even if the patients were only treated with indomethacin in the first weeks following the operation. 27,46 There are also studies describing the influence of NSAIDs in osteogenesis.…”

Section: Discussionmentioning

confidence: 89%

The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model

Urrutia

Mardones

Quezada

2007

SPI

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Object Several reports have shown that nonsteroidal antiinflammatory drugs (NSAIDs) have an inhibitory effect in osteogenesis and reduce heterotopic ossification in humans. A deleterious effect of NSAIDs in posterolateral intertransverse process fusion has also been suggested. The authors used a validated rabbit model to try to determine the influence of the NSAID ketoprophen on the fusion rate in lumbar spinal arthrodesis. Methods Thirty New Zealand male rabbits underwent posterolateral (intertransverse process) bilateral spinal fusions at a single level, using autologous bone graft obtained from both iliac crests. The animals were randomized after the operation, so that 15 rabbits received ketoprophen as a postoperative analgesic and the other 15 received the postoperative analgesic tramadol. The animals were killed 8 weeks after surgery, and fusion status was determined by inspection, palpation, anteroposterior radiographs, and histological analysis. Results A solid fusion was obtained in eight rabbits (53%), and pseudarthrosis in seven rabbits (47%) in each group. Conclusions These findings suggest that the use of ketoprophen after intertransverse spinal fusion at a single level does not decrease the fusion rate, compared with tramadol.

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Heterotopic bone formation following hip arthroplasty: A retrospective study of 65 bilateral cases

Cited by 10 publications

References 15 publications

Incidence of heterotopic bone formation after major hip surgery

Incidence of heterotopic bone formation after major hip surgery

Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva

The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model

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