Heterosynaptic Molecular Dynamics: Locally Induced Propagating Synaptic Accumulation of CaM Kinase II

Rose, Jacqueline K.; Jin, Shan-Xue; Craig, Ann Marie

doi:10.1016/j.neuron.2008.12.030

Cited by 95 publications

(129 citation statements)

References 39 publications

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“…Interestingly, it has been shown that an alteration of the inhibitory phosphorylation function of the Ca 2+ /calmodulin‐dependent protein kinase II (CamKII) is coupled to an increase in AMPA receptors expressed at the synapse (Rose, Jin, & Craig, 2009). In addition, mutations affecting this critical site of CamKII were shown to prevent the behavioral deficit in UBE3A gene‐altered mice, suggesting that the Angelman syndrome is associated with a perturbation of CamKII functions (van Woerden et al., 2007; Figure 1).…”

Section: Reviewmentioning

confidence: 99%

Autism throughout genetics: Perusal of the implication of ion channels

et al. 2018

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BackgroundAutism spectrum disorder (ASD) comprises a group of neurodevelopmental psychiatric disorders characterized by deficits in social interactions, interpersonal communication, repetitive and stereotyped behaviors and may be associated with intellectual disabilities. The description of ASD as a synaptopathology highlights the importance of the synapse and the implication of ion channels in the etiology of these disorders.MethodsA narrative and critical review of the relevant papers from 1982 to 2017 known by the authors was conducted.ResultsGenome‐wide linkages, association studies, and genetic analyses of patients with ASD have led to the identification of several candidate genes and mutations linked to ASD. Many of the candidate genes encode for proteins involved in neuronal development and regulation of synaptic function including ion channels and actors implicated in synapse formation. The involvement of ion channels in ASD is of great interest as they represent attractive therapeutic targets. In agreement with this view, recent findings have shown that drugs modulating ion channel function are effective for the treatment of certain types of patients with ASD.ConclusionThis review describes the genetic aspects of ASD with a focus on genes encoding ion channels and highlights the therapeutic implications of ion channels in the treatment of ASD.

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Section: Reviewmentioning

confidence: 99%

Autism throughout genetics: Perusal of the implication of ion channels

et al. 2018

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“…2. This is a reasonable approximation, since the Ca 2+ spike travels much faster than the CaMKII translocation wave (Rose et al 2009). Thus by the time a significant amount of activated CaMKII has diffused into non-stimulated regions of the dendrite, any CaMKII encountered there will already be primed.…”

Section: Model Of Camkii Translocation Wavesmentioning

confidence: 98%

“…Our previous mathematical model of CaMKII translocation waves within a dendrite (Earnshaw and Bressloff 2010) is based upon an experimentally motivated mechanism proposed by Rose et al (2009), which is illustrated in Fig. 2.…”

Section: Model Of Camkii Translocation Wavesmentioning

confidence: 99%

“…They found translocation waves in both excitatory pyramidal neurons and inhibitory interneurons for both the α and β isoforms of CaMKII. Moreover, the CaMKII translocation wave was associated with an increase in AMPA receptor numbers at both stimulated and non-stimulated synapses (Rose et al 2009). This suggests that it could provide a possible molecular substrate for heterosynaptic plasticity.…”

Section: Introductionmentioning

confidence: 99%

“…Following Rose et al (2009), we assumed that CaMKII exists in either a primed (P) or activated (A) state and only the latter can translocate into spines. We derived a simple formula for the speed of translocation waves given by c = 2 √ D(k − h), where D is the cytosolic diffusivity of CaMKII, k is the effective activation rate for the irreversible reaction A + P → 2 A, and h is the global translocation rate.…”

Section: Introductionmentioning

confidence: 99%

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Propagation of CaMKII translocation waves in heterogeneous spiny dendrites

Bressloff

2012

J. Math. Biol.

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CaMKII (Ca 2+ -calmodulin-dependent protein kinase II) is a key regulator of glutamatergic synapses and plays an essential role in many forms of synaptic plasticity. It has recently been observed experimentally that stimulating a local region of dendrite not only induces the local translocation of CaMKII from the dendritic shaft to synaptic targets within spines, but also initiates a wave of CaMKII translocation that spreads distally through the dendrite with an average speed of order 1µm/s. We have previously developed a simple reaction-diffusion model of CaMKII translocation waves that can account for the observed wavespeed and predicts wave propagation failure if the density of spines is too high. A major simplification of our previous model was to treat the distribution of spines as spatially uniform. However, there are at least two sources of heterogeneity in the spine distribution that occur on two different spatial scales. First, spines are discrete entities that are joined to a dendritic branch via a thin spine neck of submicron radius, resulting in spatial variations in spine density at the micron level. The second source of heterogeneity occurs on a much longer length scale and reflects the experimental observation that there is a slow proximal to distal variation in the density of spines. In this paper, we analyze how both sources of heterogeneity modulate the speed of CaMKII translocation waves along a spiny dendrite. We adapt methods from the study of the spread of biological invasions in heterogeneous environments, including homogenization theory of pulsating fronts and Hamilton-Jacobi dynamics of sharp interfaces.

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Changes in mid‐to‐late latency auditory evoked reponses in the chicken during neural maturation

Atkinson

Rostas

Hunter

2009

Developmental Psychobiology

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Utilizing the special advantages offered by the protracted maturation of neural circuits in chicken forebrain this study investigates the functional consequence of maturation using auditory evoked response potentials (AERPs) in behaving animals. Repeated measures AERP recordings were undertaken between weeks 1 and 8 posthatch. Quantitative analysis revealed a significant decrease in amplitude of the positive AERP component and a decrease in latency of the negative AERP component with maturation. AERPs were also utilized to investigate perturbed maturation via the induction of chemically induced hypothyroidism. Results from this study showed that the induction of late onset hypothyroidism produces measurable effects on the chicken AERP consistent with perturbation in maturation of neuronal circuits and synapses. This suggests that AERPs may be useful noninvasive functional measures of brain maturation that can be used to study the effects of endogenous or exogenous factors on brain maturation in the chicken. Since human brain also exhibits a protracted maturation period the availability of a well-characterized animal model for protracted brain maturation provides an opportunity to identify molecules, genes and environmental factors that are important in the regulation of maturation. The protracted maturation of neuronal circuits observed in chicken forebrain offers such a model.

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Heterosynaptic Molecular Dynamics: Locally Induced Propagating Synaptic Accumulation of CaM Kinase II

Cited by 95 publications

References 39 publications

Autism throughout genetics: Perusal of the implication of ion channels

Autism throughout genetics: Perusal of the implication of ion channels

Propagation of CaMKII translocation waves in heterogeneous spiny dendrites

Changes in mid‐to‐late latency auditory evoked reponses in the chicken during neural maturation

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