Heterosexual experience prevents the development of conditioned same-sex partner preference in male rats

Ramírez-Rodríguez, Rodrigo; Tecamachaltzi-Silvarán, Miriam B.; Díaz-Estrada, Victor X.; Chena-Becerra, Florencia; Herrera-Covarrubias, Deissy; Paredes-Ramos, Pedro; Manzo, Jorge; Hernández, Luis García; Coria-Ávila, Genaro A.

doi:10.1016/j.beproc.2017.01.010

Cited by 6 publications

(1 citation statement)

References 67 publications

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“…Furthermore, we argue that this approach could be applied for more precise determination of specific mechanisms involved in abnormal or disturbed sexual behavior in rats that are translationally related to human health disorders. In particular, translational research in rodent models of sexual behavior has provided important insights into the pathomechanisms and pharmacotherapy of clinical conditions that are described in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM 5) and in the International Statistical Classification of Diseases and Related Health Problems 10th revision (ICD-10), including premature ejaculation, paraphilias, mood and anxiety disorders as well as neurological and metabolic diseases (McVary et al, 1997;Grønli et al, 2005;Giuliano and Clément, 2006;Hawley et al, 2013;Pfaus et al, 2013;Kang et al, 2014;Olayo-Lortia et al, 2014;Sanna et al, 2014;Faulkner et al, 2015;Babaei-Balderlou and Khazali, 2016;Oosting et al, 2016;Ramírez-Rodríguez et al, 2017;Hernández and Fernández-Guasti, 2018;Novati et al, 2018). In this light, we propose that in various rodent models of human disease states, sexual motivation and performance may be differently affected, which is reflected in distinct changes of specific components of male rat sexual behavior.…”

Section: Introductionmentioning

confidence: 99%

The Sexual Motivation of Male Rats as a Tool in Animal Models of Human Health Disorders

Bialy

Bogacki-Rychlik

Przybylski

et al. 2019

Front. Behav. Neurosci.

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Normal or dysfunctional sexual behavior seems to be an important indicator of health or disease. Many health disorders in male patients affect sexual activity by directly causing erectile dysfunction, affecting sexual motivation, or both. Clinical evidence indicates that many diseases strongly disrupt sexual motivation and sexual performance in patients with depression, addiction, diabetes mellitus and other metabolic disturbances with obesity and diet-related factors, kidney and liver failure, circadian rhythm disorders, sleep disturbances including obstructive sleep apnea syndrome, developmental and hormonal disorders, brain damages, cardiovascular diseases, and peripheral neuropathies. Preclinical studies of these conditions often require appropriate experimental paradigms, including animal models. Male sexual behavior and motivation have been intensively investigated over the last 80 years in animal rat model. Sexual motivation can be examined using such parameters as: anticipatory behavior and 50-kHz ultrasonic vocalizations reflecting the emotional state of rats, initiation of copulation, efficiency of copulation, or techniques of classical (pavlovian) and instrumental conditioning. In this review article, we analyze the behavioral parameters that describe the sexual motivation and sexual performance of male rats in the context of animal experimental models of human health disorders. Based on analysis of the parameters describing the heterogeneous and complex structure of sexual behavior in laboratory rodents, we propose an approach that is useful for delineating distinct mechanisms affecting sexual motivation and sexual performance in selected disease states and the efficacy of therapy in preclinical investigations.

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