Heteropolyacid-clay nano-composite as a novel heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolinones

Dar, Bashir Ahmad; Sahu, Akshya; Patidar, Praveen; Sharma, Parduman R.; Mupparapu, Nagaraju; Vyas, Dushyant; Maity, Sudip; Sharma, Meena; Singh, Baldev

doi:10.1016/j.jiec.2012.08.027

Cited by 29 publications

(10 citation statements)

References 25 publications

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“…MHY2245 was synthesized in house (College of Pharmacy, Pusan National University, South Korea) using anthranilamide and 1-naphthaldehyde as previously described [21]. We compared the cytotoxic effects of MHY2245 on six different human cancer cells including SKOV3 (human ovary cancer), OVCAR3 (human ovary cancer), Ishikawa (human endometrial cancer), DU145 (human prostate cancer), MCF-7 (human breast cancer) and Caki-1 (human kidney cancer) and normal cell lines (HK-2, human kidney normal tubular).…”

Section: Cytotoxicity Of Mhy2245 On Various Cancer or Normal Cell Linesmentioning

confidence: 99%

A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells

Tae¹,

Son²,

Lee³

et al. 2020

Int. J. Biol. Sci.

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Ovarian cancer is a common gynecological cancer that is found worldwide. Class III histone deacetylase (HDAC) inhibitors, a new class of anticancer agents, induce autophagy in various human cancer cells. The aim of the present study was to investigate the antitumor activity of MHY2245, a new synthetic SIRT inhibitor, on human ovarian cancer cells. We found that MHY2245 exhibited potent cytotoxicity to SKOV3 cells in a time-and concentration-dependent manner. The cytotoxicity of MHY2245 (IC 50 =0.32 µM) was higher than that of doxorubicin (DOX, IC 50 =1.38µM) against SKOV3 cells. MHY2245 significantly inhibited SIRT1 enzyme activity, reduced the expression of SIRT1, increased cell cycle arrest at G 2 /M phase, and induced apoptotic cell death in SKOV3 cells via expression of cytochrome c, cleaved-PARP, cleaved caspase-3, and Bax. This might be associated with blocking of the pyruvate kinase M2 (PKM2)/mTOR pathway. MHY2245 also inhibited tumor growth and reduced tumor size when SKOV3 cells were transplanted into nude mice. Our results indicate that MHY2245 exerts antitumor activity against ovarian cancer cells by blocking the PKM2/mTOR pathway. We suggest that MHY2245 is a promising anticancer agent that disrupts ovarian cancer cell metabolism.

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Section: Cytotoxicity Of Mhy2245 On Various Cancer or Normal Cell Linesmentioning

confidence: 99%

A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells

Tae¹,

Son²,

Lee³

et al. 2020

Int. J. Biol. Sci.

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show abstract

“…[140][141][142] The main drawbacks of this class of catalysts are low surface area and high solubility in water and conventional organic solvents. To circumvent these issues, immobilization of heteropolyacids on inorganic supports such as clays 143,144 have been suggested. More sophisticatedly, heteropolyacids can be encapsulated within a porous support.…”

Section: Functionalized Sba For Embedding Heteropolyacidsmentioning

confidence: 99%

Current advances in the utility of functionalized SBA mesoporous silica for developing encapsulated nanocatalysts: state of the art

Sadjadi

Heravi

2017

RSC Adv.

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The cavities of SBA mesoporous silica materials can be used as nanoreactors for embedding catalytic species such as nanoparticles, complexes and heteropolyacids etc. The encapsulated catalysts are renowned as superior catalytic systems regarding their catalytic activity, selectivity and reusability as well as suppressed leaching. An efficient method to improve the encapsulation of these catalysts, is in creating anchors for capturing catalytic species. It has been performed by functionalization of the surface of SBA mesoporous silica materials with various groups including sulfur, phosphorus and aminebased functional groups. The aim of this article is to review the recent advances (2014)(2015)(2016)(2017) in the field of the utility of functionalized SBA for developing encapsulated catalysts. In most cases the reusability of the catalyst and the leaching of the catalytic active species were discussed to disclose the role of functionalized SBA in heterogenizing and suppressing the leaching. Moreover, to show the superiority of these developed encapsulated catalysts, with a couple of examples we compared their catalytic activities with those of the conventional ones.

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“…In continuation of our work on environment friendly chemical transformations [21]- [26], we herein, report copper supported on ceria-zirconia as a highly stable catalyst for direct and selective hydrogenolysis of cellulose to sorbitol. To the best of our knowledge, this catalytic system has not been reported yet for the hydrgenolysis of cellulose and is one of the best performances of heterogeneous catalysts ever reported.…”

Section: Introductionmentioning

confidence: 95%

“…Sorbitol can also be fermented to ethanol via enzymatic dehydrogenation [20]. Thus, sorbitol is selected as one of the 12 top value-added products from biomass in the US DOE report [21].…”

Section: Introductionmentioning

confidence: 99%

Ceria-Based Mixed Oxide Supported CuO: An Efficient Heterogeneous Catalyst for Conversion of Cellulose to Sorbitol

Dar¹,

Khalid²,

Wani³

et al. 2015

GSC

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A series of CeO 2-Al 2 O 3 , CeO 2-TiO 2 , CeO 2-ZrO 2 , and CeO 2-SiO 2 mixed-oxide supported copper catalysts were prepared by a modified deposition-precipitation method from ultra dilute aqueous solutions and were investigated for hydrogenolysis of cellulose in aqueous medium, in the presence of hydrogen to produce sorbitol as major product. Among all the catalysts tested in the present work, CuO/CeO 2-ZrO 2 catalyst proved to be the most promising with high conversion (92%) and excellent selectivity (sorbitol 99.1%), at an intermediate reaction temperature of 245˚C in a neutral aqueous solution without an aid of liquid phase acid. The catalyst was recyclable in repeated runs and no deactivation was observed even after five reaction cycles. CuO/CeO 2-ZrO 2 has been characterized by XRD, SEM, TPR and BET surface area techniques.

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Heteropolyacid-clay nano-composite as a novel heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolinones

Cited by 29 publications

References 25 publications

A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells

A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells

Current advances in the utility of functionalized SBA mesoporous silica for developing encapsulated nanocatalysts: state of the art

Ceria-Based Mixed Oxide Supported CuO: An Efficient Heterogeneous Catalyst for Conversion of Cellulose to Sorbitol

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