Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.Aβ-induced mice

Deng, Jiahang; Feng, Xinyue; Zhou, Longjian; He, Chuantong; Li, Huilin; Xia, Juan; Ge, Yue‐Wei; Zhao, Yuntao; Song, Cai; Chen, Lei; Yang, Zhiyou

doi:10.1016/j.foodres.2022.111576

Cited by 12 publications

(8 citation statements)

References 59 publications

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“…6,24 Heterophyllin B of P. heterophylla can improve mouse memory via neurite regeneration and immunomodulation. 25 Our results showed that P. heterophylla increased the content of white and red blood cells and decreased the content of platelets following cyclophosphamide injury. This indicated that total P. heterophylla was able to improve cell immunity in mice.…”

Section: Discussionmentioning

confidence: 48%

Pseudostellaria heterophylla improves intestinal microecology through modulating gut microbiota and metabolites in mice

Zhang,

Kang,

Malacrinò

et al. 2024

J Sci Food Agric

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BackgroundPseudostellaria heterophylla is a Chinese medicine and healthy edible that is widely used to for its immunomodulatory, antioxidant, antidiabetic, and antitussive properties. However, the potential function of P. heterophylla in intestinal microecology remains unclear. In this study, we investigated the impact of P. heterophylla on immune functions and evaluated its potential to regulate the gut microbiota and metabolome.ResultsThe results showed that P. heterophylla significantly increased the content of red blood cells, total antioxidant capacity, and expression of immune factors, and decreased platelet counts when compared to the control under cyclophosphamide injury. In addition, P. heterophylla altered the diversity and composition of the gut bacterial community; increased the abundance of potentially beneficial Akkermansia, Roseburia, unclassified Clostridiaceae, Mucispirillum, Anaeroplasma and Parabacteroides; and decreased the relative abundance of pathogenic Cupriavidus and Staphylococcus in healthy mice. Metabolomic analyses showed that P. heterophylla significantly increased the content of functional oligosaccharides, common oligosaccharides, vitamins, and functional substances. Probiotics and pathogens were regulated by metabolites across 11 pathways in the bacterial–host co‐metabolism network.ConclusionWe demonstrated that P. heterophylla increased the abundance of probiotics and decreased pathogens, and further stimulated host microbes to produce beneficial secondary metabolites for host health. Our studies highlight the role of P. heterophylla on gut health, and provided the new insights for the development of traditional Chinese medicine in the diet.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 48%

Pseudostellaria heterophylla improves intestinal microecology through modulating gut microbiota and metabolites in mice

Zhang,

Kang,

Malacrinò

et al. 2024

J Sci Food Agric

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“…Neuroprotective effects of azaphilones against Aβ 25-35induced neurotoxicity were assessed in primary cultured cortical neurons. 20 Among the ten tested compounds, 8 and 9 showed significant neuronal protective effects against Aβ 25-35induced neuronal death at a concentration of 10 μM (Fig. 8).…”

Section: Papermentioning

confidence: 91%

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

Chen,

Jiang,

Pang

et al. 2024

Org. Biomol. Chem.

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“…The microbial DNA was extracted using a Genomic DNA Kit, as previously stated. 25,26 16S rDNA gene sequencing (V3-V4 regions) was detected and amplified from the whole genome using the barcoded 338F/806R primer pair. All the amplicons were purified, quantified, and finally sequenced on an Illumina NovaSeq (CA, USA).…”

Section: S Rdna Analysis Of Gut Microbiotamentioning

confidence: 99%

A combined effect of fish-originated collagen peptides and caffeine on the cognitive function of sleep-deprived mice

Zhu,

Bai,

et al. 2024

Food Funct.

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Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.Aβ-induced mice

Cited by 12 publications

References 59 publications

Pseudostellaria heterophylla improves intestinal microecology through modulating gut microbiota and metabolites in mice

Pseudostellaria heterophylla improves intestinal microecology through modulating gut microbiota and metabolites in mice

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

A combined effect of fish-originated collagen peptides and caffeine on the cognitive function of sleep-deprived mice

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