Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.Aβ-induced mice

Deng, Jiahang; Feng, Xinyue; Zhou, Longjian; He, Chuantong; Li, Huilin; Xia, Juan; Ge, Yue‐Wei; Zhao, Yuntao; Song, Cai; Chen, Lei; Yang, Zhiyou

doi:10.1016/j.foodres.2022.111576

Cited by 10 publications

(4 citation statements)

References 59 publications

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“…Neuroprotective effects of azaphilones against Aβ 25-35induced neurotoxicity were assessed in primary cultured cortical neurons. 20 Among the ten tested compounds, 8 and 9 showed significant neuronal protective effects against Aβ 25-35induced neuronal death at a concentration of 10 μM (Fig. 8).…”

Section: Papermentioning

confidence: 91%

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

Chen,

Jiang,

Pang

et al. 2024

Org. Biomol. Chem.

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Section: Papermentioning

confidence: 91%

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

Chen,

Jiang,

Pang

et al. 2024

Org. Biomol. Chem.

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“…The microbial DNA was extracted using a Genomic DNA Kit, as previously stated. 25,26 16S rDNA gene sequencing (V3-V4 regions) was detected and amplified from the whole genome using the barcoded 338F/806R primer pair. All the amplicons were purified, quantified, and finally sequenced on an Illumina NovaSeq (CA, USA).…”

Section: S Rdna Analysis Of Gut Microbiotamentioning

confidence: 99%

A combined effect of fish-originated collagen peptides and caffeine on the cognitive function of sleep-deprived mice

Zhu,

Bai,

et al. 2024

Food Funct.

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“…It is well-regarded for its notable pharmacological effects, including antioxidant properties, hypoglycemia effects, anti-fatigue benefits, and memory improvement ( 96 ). Heterophyllin B, a occurring cyclic peptide naturally purified from Radix Pseudostellariae, exhibits anti-inflammatory and antioxidant properties ( 97 , 98 ). Researches have showed that heterophyllin B can reduce myofibroblast recruitment and ECM deposition via blocking the AMPK-STING pathway.…”

Section: Targeting Cgas-sting Signaling Alleviates Pulmonary Fibrosismentioning

confidence: 99%

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

Zhang,

Chen

et al. 2023

Front. Immunol.

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Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow down the progression of pulmonary fibrosis, they are unable to reverse the disease. Therefore, there is an urgent demand to develop more efficient therapeutic approaches for pulmonary fibrosis. The intracellular DNA sensor called cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) plays a crucial role in detecting DNA and generating cGAMP, a second messenger. Subsequently, cGAMP triggers the activation of stimulator of interferon genes (STING), initiating a signaling cascade that leads to the stimulation of type I interferons and other signaling molecules involved in immune responses. Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This review aims to provide a comprehensive summary of the current knowledge regarding the role of cGAS-STING pathway in pulmonary fibrosis. Moreover, we discuss the potential therapeutic implications of targeting the cGAS-STING pathway, including the utilization of inhibitors of cGAS and STING.

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Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.Aβ-induced mice

Cited by 10 publications

References 59 publications

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

Neuroprotective azaphilones from a deep-sea derived fungus Penicillium sp. SCSIO41030

A combined effect of fish-originated collagen peptides and caffeine on the cognitive function of sleep-deprived mice

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

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