Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response

Cheng, Wei; Yang, Fan; Liu, Shuang; Colton, Craig K.; Wang, Chunbo; Cui, Yuanyuan; Cao, Xu; Zhu, Michael X.; Sun, Changsen; Wang, Ke Wei; Zheng, Jie

doi:10.1074/jbc.m111.305045

Cited by 70 publications

(80 citation statements)

References 46 publications

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“…Farnesyl pyrophosphate was shown to activate TRPV3 in heterologous expression systems 104 , whereas its precursor, isopentenyl pyrophosphate, inhibits the channel 39, 105 . Interestingly, one report indicates that TRPV3 subunits can form active heteromultimeric channels with TRPV1 subunits in HEK293 cells expressing a cDNA construct encoding a fused TRPV1/TRPV3 protein 106 . The resulting channels exhibit a unitary conductance and temperature sensitivity that is intermediate compared to the respective homomeric channels and increased sensitivity to capsaicin compare to TRPV1 homomeric channels 106 .…”

Section: S-nytrosylation Of Trpv3 Channelsmentioning

confidence: 99%

Redox regulation of transient receptor potential channels in the endothelium

Pires

Earley

2017

Microcirculation

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important mediators of signaling pathways in the endothelium. Specific members of the transient receptor potential (TRP) superfamily of cation channels act as important Ca2+ influx pathways in endothelial cells, and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review we highlight the recent literature describing in redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.

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Section: S-nytrosylation Of Trpv3 Channelsmentioning

confidence: 99%

Redox regulation of transient receptor potential channels in the endothelium

Pires

Earley

2017

Microcirculation

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“…Foremost is the potential for different levels of expression and differing sensitivity of receptors across species or cell preparations (Bandell et al 2007; Klein et al 2011; Riera et al 2009). Also, receptor proteins may form heteromeric dimers and tetramers in native systems, so data from the cell culture work should be interpreted cautiously to avoid reductionism, as heteromers show altered functionality that cannot be replicated in heterologously expressed systems (Cheng et al 2012; Fischer et al 2014). Critically, data on a) species specific differences in TRP channel responses, and b) differences between the peripheral and central nervous systems are lacking, and additional multidisciplinary research is needed to enhance our understanding of chemesthesis.…”

Section: Discussionmentioning

confidence: 99%

Perceptual Mapping of Chemesthetic Stimuli in Naive Assessors

Byrnes

Nestrud²,

Hayes

2015

Chem. Percept.

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Chemesthetic compounds, responsible for sensations such as burning, cooling, and astringency, are difficult stimuli to work with, especially when the evaluation task requires retasting. Here, we developed a protocol by which chemesthetic compounds can be assessed using sorting. We compared the performance of two cohorts of untrained assessors on this task, one with nose clips and the other without. Similarity matrices were analyzed using multidimensional scaling (MDS) to produce perceptual maps for the two cohorts. Overall, the groupings from the nose open cohort tended to follow a biological basis, consistent with previous findings that suggest compounds that activate a common receptor will elicit similar sensations. The nose-open and nose-pinched cohorts generated significantly different maps. The nose-pinched cohort had a higher variance in the MDS solution than the nose-open group. While the nose-open cohort generated seven clusters, the nose-pinched cohort generated only two clusters, seemingly based on the ready identification of chemesthetic sensations or not. There was less consensus regarding the attributes used to describe the samples in the nose-pinched cohort than in the nose-open cohort as well, as this cohort collectively generated more attributes but fewer were significant in regression.

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“…Alone, or perhaps in heteromeric confirmation with TRPV1, TRPV3 provides a temperature stimulated calcium conductance in the same temperature range that drives spontaneous release independently of TRPV1 (33-39°C) [38, 39]. Preliminary electrophysiological studies using transgenic TRPV1 KO mice suggest that TRPV3 may drive some of the remaining asynchronous release at the ST-NTS synapse independent of TRPV1 and maintain the temperature sensitivity of spontaneous release.…”

Section: Vagal Afferent ‘Trp’ Channel Expressionmentioning

confidence: 99%

Channeling satiation: A primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons

Fenwick

Peters

2014

Physiology & Behavior

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Obesity results from the chronic imbalance between food intake and energy expenditure. To maintain homeostasis, the brainstem nucleus of the solitary tract (NTS) integrates peripheral information from visceral organs and initiates reflex pathways that control food intake and other autonomic functions. This peripheral-to-central neural communication occurs through activation of vagal afferent neurons which converge to form the solitary tract (ST) and synapse with strong glutamatergic contacts onto NTS neurons. Vagal afferents release glutamate containing vesicles via three distinct pathways (synchronous, asynchronous, and spontaneous) providing multiple levels of control through fast synaptic neurotransmission at ST-NTS synapses. While temperature at the NTS is relatively constant, vagal afferent neurons express an array of thermosensitive ion channels named transient receptor potential (TRP) channels. Here we review the evidence that TRP channels pre-synaptically control quantal glutamate release and examine the potential roles of TRP channels in vagally mediated satiety signaling. We summarize the current literature that TRP channels contribute to asynchronous and spontaneous release of glutamate which can distinctly influence the transfer of information across the ST-NTS synapse. In other words, multiple glutamate vesicle release pathways, guided by afferent TRP channels, provide for robust while adaptive neurotransmission and expand our understanding of vagal afferent signaling.

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Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response

Cited by 70 publications

References 46 publications

Redox regulation of transient receptor potential channels in the endothelium

Redox regulation of transient receptor potential channels in the endothelium

Perceptual Mapping of Chemesthetic Stimuli in Naive Assessors

Channeling satiation: A primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons

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