Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron
Daniela Bottero,
Erika Rudi,
Pablo Martin Aispuro
et al.
Abstract:In this study, we evaluated the efficacy of a heterologous three-dose vaccination schedule against the Omicron BA.1 SARS-CoV-2 variant infection using a mouse intranasal challenge model. The vaccination schedules tested in this study consisted of a primary series of 2 doses covered by two commercial vaccines: an mRNA-based vaccine (mRNA1273) or a non-replicative vector-based vaccine (AZD1222/ChAdOx1, hereafter referred to as AZD1222). These were followed by a heterologous booster dose using one of the two vacc… Show more
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