Heterogenous properties of dentate granule neurons in the adult rat

Wang, Sabrina; Scott, Bradley; Wojtowicz, J. Martin

doi:10.1002/(sici)1097-4695(20000205)42:2<248::aid-neu8>3.0.co;2-j

Cited by 379 publications

(303 citation statements)

References 37 publications

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“…This is in accordance with the observation that NeuN is expressed preferentially in areas of low chromatin density (Lind et al, 2005), indicating a higher cell activity in large granule cells. Thus, large granule cells may be also functionally related to adult born granule cells, as these cells have been shown to be more excitable than the resident granule cells (Schmidt-Hieber et al, 2004;Wang et al, 2000).…”

Section: Resident Granule Cells and Their Relation To Neurogenesismentioning

confidence: 99%

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Amrein¹,

Slomianka²

2010

Brain Research

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A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis Running titleThe dentate gyrus of the red fox Text pages 37Figures 7 Tables 3 Corresponding authorIrmgard In summary, we report a morphologically distinct granule cell type which correlates with adult 3 hippocampal neurogenesis in the fox. Furthermore, the maturation phase of the young neurons may be prolonged as in other long-living species such as primates. SECTIONNervous System Development, Regeneration and Aging

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Section: Resident Granule Cells and Their Relation To Neurogenesismentioning

confidence: 99%

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Amrein¹,

Slomianka²

2010

Brain Research

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“…They receive synaptic input (Kaplan and Hinds, 1977;Kaplan and Bell, 1983;Markakis and Gage, 1999;Carlén et al, 2002), send axonal projections to appropriate targets in hippocampal area CA3 (Stanfield and Trice, 1988;Hastings and Gould, 1999;Markakis and Gage, 1999), and acquire the electrophysiological properties of mature granule neurons (Wang et al, 2000;Song et al, 2002b;van Praag et al, 2002). Although the precise function of DGCs generated in adulthood is unknown, experimental depletion of new neurons disrupts the formation of some types of memory (Shors et al, 2001), suggesting that the new neurons play a role in hippocampal-dependent learning and memory.…”

Section: Dentate Gyrusmentioning

confidence: 99%

Adult Neurogenesis and the Ischemic Forebrain

Lichtenwalner

Parent

2005

J Cereb Blood Flow Metab

261

190

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The recent identification of endogenous neural stem cells and persistent neuronal production in the adult brain suggests a previously unrecognized capacity for self-repair after brain injury. Neurogenesis not only continues in discrete regions of the adult mammalian brain, but new evidence also suggests that neural progenitors form new neurons that integrate into existing circuitry after certain forms of brain injury in the adult. Experimental stroke in adult rodents and primates increases neurogenesis in the persistent forebrain subventricular and hippocampal dentate gyrus germinative zones. Of greater relevance for regenerative potential, ischemic insults stimulate endogenous neural progenitors to migrate to areas of damage and form neurons in otherwise dormant forebrain regions, such as the neostriatum and hippocampal pyramidal cell layer, of the mature brain. This review summarizes the current understanding of adult neurogenesis and its regulation in vivo, and describes evidence for stroke-induced neurogenesis and neuronal replacement in the adult. Current strategies used to modify endogenous neurogenesis after ischemic brain injury also will be discussed, as well as future research directions with potential for achieving regeneration after stroke and other brain insults.

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“…Adult-born neurons in the dentate gyrus exhibit the electrophysiological properties of granule neurons (Song et al, 2002;van Praag et al, 2002;Wang et al, 2000) and form mossy fiber projections to area CA3 (Hastings and Gould, 1999;Markakis and Gage, 1999;Stanfield and Trice, 1988), suggesting that they play an important role in activity-dependent hippocampal physiology. Indeed, external stimuli, such as exercise and hippocampal-dependent learning paradigms increase adult neural stem/ progenitor cell proliferation within the subgranular zone (SGZ) Olson et al, 2006) and manipulations that inhibit neurogenesis disrupt memory formation (Shors et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

Choi

Cho

Hoyt

et al. 2008

Glia

132

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Adult progenitor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus is a dynamic process that is modulated by an array of physiological process, including locomotor activity and novel environmental stimuli. In addition, pathophysiological events, such as ischemia and status epilepticus (SE), have been shown to stimulate neurogenesis. Currently, limited information is available regarding the extracellular stimuli, receptors, and downstream intracellular effectors that couple excitotoxic stimulation to progenitor cell proliferation. Here we show that pilocarpineinduced SE triggers a set of signaling events that impinge upon the p42/44 mitogen-activated protein kinase (MAPK) pathway to drive progenitor cell proliferation in the SGZ at 2-days post-SE. Increased proliferation was dependent on insulin-like growth factor-1 (IGF-1), which was localized to activated microglia near the SGZ. Using a combination of techniques, we show that IGF-1 is a CREB-regulated gene and that SE triggered CRE-dependent transcription in microglia at 2-days post-SE. Together, these data identify a potential signaling program that couples SE to progenitor cell proliferation. SE triggers CREB-dependent transcription in reactive microglia. As a CREB-target gene, IGF-1 expression is upregulated, and by 2-days post-SE, IGF-1 triggers MAPK pathway activation in progenitor cells and, in turn, an increase in progenitor cell proliferation.

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Heterogenous properties of dentate granule neurons in the adult rat

Cited by 379 publications

References 37 publications

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis

Adult Neurogenesis and the Ischemic Forebrain

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

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