“…Other reports suggest that these factors are likely associated with childhood adversity and ADS later in life (Kauhanen et al, 2011 ; Lemos et al, 2012 ; Kim et al, 2013 ; Mersky et al, 2013 ; Campbell et al, 2016 ; Nurius et al, 2016 ). Consequently, several studies have indicated that education, alcohol intake, and social support mediate the association between childhood adversity and ADS in adulthood (Nurius et al, 2015 ; Openshaw et al, 2015 ; Shevlin et al, 2015 ; Lê-Scherban et al, 2016 ; Muller, 2016 ; Ni et al, 2016 ; Sheikh et al, 2016a , b ; Tani et al, 2016 ; Korhonen et al, 2017 ; Kwon and Park, 2017 ; Lee et al, 2017 ; Markkula et al, 2017 ; Wielaard et al, 2017 ) and suggested that these are important mediator-response confounding factors that must be included in analytical models in order to assess the indirect effect of childhood adversity on ADS in adulthood via smoking. It is plausible that if the mediating role of smoking is assessed without controlling for key mediator-response confounding variables, the observed indirect effect may be biased upwards (or will be statistically significant), not because smoking alone mediates the association between childhood adversity and ADS, but because of the correlation between smoking and an unmeasured (or unaccounted for) mediator-response confounder.…”