Heterogeneous Slowdown of Dynamics in the Condensate of an Intrinsically Disordered Protein
Saumyak Mukherjee,
Lars V Schäfer
Abstract:The high concentration of proteins and other biological macromolecules inside biomolecular condensates leads to dense and confined environments, which can affect the dynamic ensembles and the time scales of the conformational transitions of the biomolecules. Here we use atomistic molecular dynamics (MD) simulations on the intrinsically disordered low complexity domain (LCD) of the human fused in sarcoma (FUS) RNA-binding protein as a model system to study how self-crowding inside a condensate affects the dynam… Show more
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