Heterogeneous immunoreactivity of glial cells in the mesencephalon of a lizard: A double labeling immunohistochemical study

Monzon-Mayor, M; Yanes, C.; Barry, Jean de; Capdevilla-Carbonell, Carmen; Renau‐Piqueras, Jaime; Tholey, G.; Gombos, G.

doi:10.1002/(sici)1097-4687(199802)235:2<109::aid-jmor2>3.0.co;2-4

Cited by 20 publications

(10 citation statements)

References 25 publications

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“…Up-regulation of GS in astrocytes could be induced by neurotoxic effects of glutamate, an excitatory neurotransmitter present in the extracellular microenvironment, in an attempt to protect the nervous tissue, as Gorovits et al (1997) suggested for the rat retina. Previous studies have demonstrated that, during the ontogeny of the lizard brain, GS is expressed in radial cells (Monzon-Mayor et al, 1998). In adult brains, astrocytes in the SVZ have shown proliferative and neurogenic capacities.…”

Section: Reaction Of Astrocytes In the Svz-ob Pathway After Brain Injmentioning

confidence: 99%

Glial fibrillary acidic protein‐expressing cells in the neurogenic regions in normal and injured adult brains

Zhu

Dahlström

2007

J of Neuroscience Research

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In the adult brain, neurogenic stem cells are prevalent in the subventricular zone (SVZ) of the lateral ventricle wall and the subgranular zone (SGZ) in the dentate gyrus. Cells that have structural and molecular characteristics of astrocytes function as neurogenic stem cells in these regions, in which these cells also participate in the creation of the microenvironment that stimulates neurogenesis. In the present paper, we review the phenotypic properties, subpopulations, and proliferation of glial fibrillary acidic protein (GFAP)-expressing cells in these two neurogenic regions and their responses to different brain injuries. Cells fulfilling the criteria for astrocytes, i.e., expressing GFAP, in the SVZ and SGZ respond differently to brain injuries or neurogenic stimuli. The importance of guidance by astrocytes of newly formed neuronal cells is emphasized. The assessment of GFAP-expressing cells in the neurogenic regions is of great importance for understanding the mechanism underlying the response of neural stem cells to brain injury.

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Section: Reaction Of Astrocytes In the Svz-ob Pathway After Brain Injmentioning

confidence: 99%

Glial fibrillary acidic protein‐expressing cells in the neurogenic regions in normal and injured adult brains

Zhu

Dahlström

2007

J of Neuroscience Research

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“…The presence of these intermediate filament molecular markers in the different astroglial cell types, as well as the relative proportion and the regional distribution of these astrocytic subtypes in the central nervous system (CNS) of different vertebrates appear very important in ontogenetic and phylogenetic studies (Elmquist et al 1994;Monzon-Mayor et al 1998;Kalman and Pritz 2001;Lazzari and Franceschini 2001).…”

Section: Introductionmentioning

confidence: 99%

Intermediate filament immunohistochemistry of astroglial cells in the leopard gecko, Eublepharis macularius

Lazzari

Franceschini

2005

Anat Embryol

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The distribution of intermediate filament molecular markers, glial fibrillary acidic protein (GFAP) and vimentin, has been studied in the central nervous system (CNS) of the adult leopard gecko, Eublepharis macularius. This immunohistochemical study points out the presence of different astroglial cell types. The main pattern is constituted by ependymal radial glia, which have their cell bodies located in the ependymal layer throughout the brain ventricular system. Radial glia proper or radial astrocytes show their cell bodies displaced from the ependymal layer into a periependymal zone and are observed only in the spinal cord. Star-shaped astrocytes are scarce. They are detected in the ventral and lateral regions of the diencephalon and mesencephalon, in the superficial layer of the optic tectum, in the ventral medulla oblongata, and in the ventral and lateral spinal cord. In the different regions of the CNS, the staining intensity appears not to be identical even in the same cellular type. The results reported in the present study show an heterogeneous feature of the astroglial pattern in E. macularius.

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“…Among TfBP + cells, OLGs were the most prominent cell type, which was distributed all over the turtle central nervous system (CNS) with a high density in the white matter and very sparse population in the gray matter. Our findings are the first report of OLG distribution in the reptile brain as previous studies using antibodies for several myelin components including MBP, proteolipid protein (PLP), or myelin-associated glycoprotein (MAG), S100 protein, and glutamine synthetase were unsuccessful in demonstrating OLGs in the adult lizard brain (Birling and Nussbaum, 1995;Monzón-Mayor et al, 1998;Romero-Aleman Mdel et al, 2003;Santos et al, 2006). In this respect, our results showing TfBP as a marker for reptilian oligodendrocytes constitute the basis for comparative and phylogenic studies of the brain, particularly its glial components.…”

Section: Discussionmentioning

confidence: 48%

“…Electron microscopic studies in the turtle have demonstrated that the animals possess macroglial cells that are similar to those found in mammals (Geri et al, 1982;Rainey and Ulinski, 1982;Davila et al, 1987), and recent studies have described GFAP and vimentin expression in astrocytes (Kalman et al, 1997;Lazzari and Franceschini, 2006). However, while a few studies have demonstrated OLGs and myelination in the developing and adult reptile brain, little is known about the immunohistochemical detection of OLGs in the reptile nervous system (Birling and Nussbaum, 1995;Monzón-Mayor et al, 1998;Romero-Aleman Mdel et al, 2003;Santos et al, 2006). This study was therefore designed to study OLGs in the turtle nervous system by using the antibody for transferrin binding protein (TfBP).…”

Section: Introductionmentioning

confidence: 98%

The expression of transferrin binding protein in the turtle nervous system

Lee

Jeon

Sim

et al. 2009

Archives of Histology and Cytology

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Heterogeneous immunoreactivity of glial cells in the mesencephalon of a lizard: A double labeling immunohistochemical study

Cited by 20 publications

References 25 publications

Glial fibrillary acidic protein‐expressing cells in the neurogenic regions in normal and injured adult brains

Glial fibrillary acidic protein‐expressing cells in the neurogenic regions in normal and injured adult brains

Intermediate filament immunohistochemistry of astroglial cells in the leopard gecko, Eublepharis macularius

The expression of transferrin binding protein in the turtle nervous system

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