Abstract:Stem cell homeostasis in the shoot apical meristem involves a core regulatory feedback loop between the signalling peptide CLAVATA3, produced in stem cells, and the transcription factor WUSCHEL, expressed in the underlying organising centre. Compromised CLAVATA activity leads to massive meristem overgrowth, which is thought to be caused by stem cell overproliferation. However, it is unknown how uncontrolled stem cell divisions lead to the specific changes observed inclavatamutants. Here we first quantitatively… Show more
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