Heterogeneous gold nanocatalyst applied in the synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones

Fe3O4@Sap/Cu(ii): an efficient magnetically recoverable green nanocatalyst for the preparation of acridine and quinazoline derivatives in aqueous media at room temperature

“…39 In addition, one-pot three-component condensation reaction of (a) aromatic aldehydes, phenylhydrazine, and isatoic anhydride or (b) aromatic aldehydes, 2-aminobenzophenone, and ammonium acetate, for the synthesis of quinazolines are the common and key reactions in the synthesis of these compounds. 40 To now, several methods have been reported for the one-pot multi-component condensation synthesis of acridine and quinazoline derivatives, 41 employing a wide variety of catalysts such as Fe 3 O 4 /HT-SMTU-Zn II , 42 SBA/AuNP, 43 [Nbdm][OH], 44 Co-aminobenzamid@Al-SBA-15, 45 a-chymotrypsin, 46 Pd(OAc) 2 , 47 KCC-1/Pr-SO 3 H, 48 and CuCl 2 , 49 Co-alanine complex, 50 55 Despite the usefulness of these catalysts, they also have some limitations including high toxicity, use of expensive materials, complex synthetic processes, long reaction times, and sometimes low yields.…”

“…To now, several methods have been reported for the one-pot multi-component condensation synthesis of acridine and quinazoline derivatives, 41 employing a wide variety of catalysts such as Fe 3 O 4 /HT-SMTU-Zn II , 42 SBA/AuNP, 43 [Nbdm][OH], 44 Co-aminobenzamid@Al-SBA-15, 45 α-chymotrypsin, 46 Pd(OAc) 2 , 47 KCC-1/Pr-SO 3 H, 48 and CuCl 2 , 49 Co–alanine complex, 50 magnetic praseodymium nanocatalyst, 51 nano-Fe 3 O 4 -DOPA-SnO 2 , 52 MNPs-NPB-SO 3 H, 53 SDS 54 and bentonite. 55 Despite the usefulness of these catalysts, they also have some limitations including high toxicity, use of expensive materials, complex synthetic processes, long reaction times, and sometimes low yields.…”

Selective Synthesis of Benzimidazoles from o-Phenylenediamine and Aldehydes Promoted by Supported Gold Nanoparticles

“…Of note is that only the synthesis of 2-phenyl-1H-benzo[d]imidazole was described using Au/TiO 2 in toluene or water at 150 • C under N 2 atmosphere (Scheme 2). Additionally, AuNPs/SBA material was successfully applied for the synthesis of a series of 2-aryl-2,3-dihydroquinazoli-4(1H)-ones, as a heterogeneous catalyst in the condensation reaction between 2-aminobenzamide and aromatic aldehydes (result not shown) [71]. In all cases, high temperatures and prolonged reaction time were necessary for reaction completion.…”

Immobilization of nickel on Kryptofix 222 modified Fe3O4@PEG core‐shell nanosphere for the clean synthesis of 2‐Aryl‐2,3‐dihydroquinazolin‐4(1H)‐ones

“…Finally, 1 HNMR and 13 CNMR spectroscopy were used to identify the products (details in supporting information) and then compared with the reported scientific findings. [ 33,34 ]…”