Heterogeneous distribution of mechanical stress in human lung: A mathematical approach to evaluate abnormal remodeling in IPF

Carloni, Angelo; Poletti, Venerino; Fermo, Luisa; Bellomo, Nicola; Chilosi, Marco

doi:10.1016/j.jtbi.2013.04.038

Cited by 52 publications

(30 citation statements)

References 23 publications

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“…Premature ageing and mechanical stress can impair lung function in different ways, affecting distinct progenitor cells and leading to stem cell exhaustion [32]. Moreover CARLONI et al [33] showed that mechanical stress may play an important role in triggering specific pathways at the periphery of the lung, providing a possible explanation for the peculiar distribution of lung fibrosis in IPF. To further support the concept that IPF is a disease of premature ageing, dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), which have been previously linked to the impaired function of the immune system occurring with ageing, have been evaluated in the serum of IPF patients [34].…”

Section: Advances In Understanding the Pathogenetic Mechanisms Of Ipfmentioning

confidence: 99%

Interstitial lung disease

Αντωνίου

Margaritopoulos

Tomassetti

et al. 2014

European Respiratory Review

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Interstitial lung diseases are a group of diffuse parenchymal lung disorders associated with substantial morbidity and mortality. Knowledge achieved in recent years has resulted in the publication of the new classification of idiopathic interstitial pneumonias, according to which there are three groups: major, rare and unclassified. The novelty of the new classification comes from the fact that difficult to classify entities can be treated according to the disease behaviour classification. Idiopathic pulmonary fibrosis is the most lethal amongst the interstitial lung diseases and presents high heterogeneity in clinical behaviour. A number of biomarkers have been proposed in order to predict the course of the disease and group patients with the same characteristics in clinical trials. Early diagnosis and disease stratification is also important in the field of other interstitial lung diseases.

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Section: Advances In Understanding the Pathogenetic Mechanisms Of Ipfmentioning

confidence: 99%

Interstitial lung disease

Αντωνίου

Margaritopoulos

Tomassetti

et al. 2014

European Respiratory Review

Self Cite

216

137

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“…As such, DSP may be particularly important in the regions of the lung that experience constant mechanical stress, such as the peripheral and basilar segments, those that are preferentially affected in IPF patients [56]. Intriguingly, other investigations have illustrated that DSP acts as a tumor suppressor by suppressing the WNT/β -caten in pathway [57], a pathway that itself has been implicated in the pathogenesis of IPF [58-60].…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility and pulmonary fibrosis

Mathai

Schwartz

Warg

2014

Current Opinion in Pulmonary Medicine

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Purpose of Review Recent genetic findings have identified new targets of investigation in the field of interstitial lung diseases and have the potential to change clinical care. Recent Findings These findings implicate abnormalities in (1) host defense, (2) cell-cell adhesion, and (3) aging and senescence in the pathophysiology of pulmonary fibrosis. At least one common genetic variant strongly associated with pulmonary fibrosis appears to have prognostic implications for patients. Summary The inherited risk for pulmonary fibrosis is substantial, and recent data suggests that genetic risk for familial and sporadic forms of the disease are similar. Further characterization of the genetic risk will influence clinical practice in terms of categorization, diagnosis, and screening of individuals for this disease.

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“…The fibrotic process that characterizes IPF is commonly considered the result of recurrent injury to the alveolar epithelium followed by uncontrolled proliferation of bronchiolar epithelium and fibroblasts [2,3]. The fibrosis could arise from the most mechanically stressed areas of the lung and relentlessly progresses from the peripheral basal parenchyma to the central parenchyma and upper aspects of the lung [4]. The new pathogenetic paradigm on IPF is that it is a complex process characterized by abnormal pneumocyte apoptosis and profound derangement of alveolar renewal more similar to malignant lung disease [2,3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The fibrosis could arise from the most mechanically stressed areas of the lung and relentlessly progresses from the peripheral basal parenchyma to the central parenchyma and upper aspects of the lung [4]. The new pathogenetic paradigm on IPF is that it is a complex process characterized by abnormal pneumocyte apoptosis and profound derangement of alveolar renewal more similar to malignant lung disease [2,3,4,5]. Indeed, epigenetic and genetic abnormalities, senescence-related processes (such as oncogene-induced senescence or senescence-associated secretory phenotypes), altered cell-to-cell communications, uncontrolled proliferation and abnormal activation of specific signal transduction pathways are biological hallmarks that characterize the pathogenesis of IPF and link this disorder to lung cancer [5,6].…”

Section: Introductionmentioning

confidence: 99%

Idiopathic Pulmonary Fibrosis: Diagnosis and Prognostic Evaluation

et al. 2013

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Idiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial pneumonia and has a dismal prognosis. Median age at IPF onset is 60-70 years and it is mainly related to cigarette smoke exposure. Its clinical profile is heterogeneous and different clinical phenotypes are now better defined: familial IPF, slow and rapid progressors, combined pulmonary fibrosis and emphysema, anti-neutrophil cytoplasmic antibodies/microscopic polyangiitis and IPF, and IPF associated with lung cancer. Acute exacerbation associated with rapid functional decline is an event that does not happen infrequently and affects survival. Diagnosis requires a typical usual interstitial pneumonia (UIP) pattern on computed tomography in the appropriate clinical setting or morphological confirmation of the UIP pattern when imaging findings are not characteristic enough. Surgical lung biopsy is the gold standard to obtain valuable information for histological analysis. However, less invasive procedures (transbronchial lung biopsy or even improved transbronchial lung biopsy by cryoprobes) are now under consideration. Prognostic indicators are mainly derived by pulmonary function tests. Recently, staging systems have been proposed.

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Heterogeneous distribution of mechanical stress in human lung: A mathematical approach to evaluate abnormal remodeling in IPF

Cited by 52 publications

References 23 publications

Interstitial lung disease

Interstitial lung disease

Genetic susceptibility and pulmonary fibrosis

Idiopathic Pulmonary Fibrosis: Diagnosis and Prognostic Evaluation

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