Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications

Ness, Roberta B.; Roberts, James M.

doi:10.1016/s0002-9378(96)70056-x

Cited by 521 publications

(322 citation statements)

References 41 publications

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“…Several other studies have observed endothelial damage and dysfunction to be a common pathological feature in the disease. 10,11 Severe pregnancy complications such as severe PE, intrauterine growth retardation, abruption placenta and intrauterine fetal death are associated with thrombophilia. There are three mutations connected to thrombophilia that have been well studied.…”

Section: Introductionmentioning

confidence: 99%

High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR

2006

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Our aim was to determine the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in hypertensive disorders during pregnancy. We conducted our experiments on isolated DNA samples of 73 healthy pregnant, 101 severe pre-eclamptic and 63 HELLP syndrome women in this study. The MTHFR C677T polymorphism was determined by quantitative real-time PCR method. A significantly higher number of the TT genotype (25.4%) was found in the HELLP syndrome group compared to the healthy (8.2%) and severe preeclamptics group (8.9%) (P ¼ 0.03). The frequency of the mutant T allele was found to be 45.2% of HELLP syndrome, whereas it was 32.2% of the healthy pregnant (P ¼ 0.03) and 30.2% (P ¼ 0.008) of the severe preeclamptic patients. In the HELLP group a high frequency of eclampsia was observed (12.6%) and among them 75% had the MTHFR C677T mutation.

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Section: Introductionmentioning

confidence: 99%

High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR

2006

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“…Heterogenous causes have been implicated in the preeclampsia syndrome [13,14]. There are both placental and maternal factors that predispose to an excessive maternal inflammatory response syndrome [7].…”

Section: Introductionmentioning

confidence: 99%

Blood glutathione redox status in gestational hypertension

Németh

Orvos

Boda

2001

Free Radical Biology and Medicine

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Abstract-Gestational hypertension during the third trimester reflects an exaggerated maternal inflammatory response to pregnancy. We hypothesized that oxidative stress present even in normal pregnancy becomes uncompensated in hypertensive patients. A glucose-6-phosphate dehydrogenase (G6PD) activity sufficient to meet the increased reductive equivalent need of the cells is indispensable for defense against oxidative stress. The erythrocyte glutathione redox system was studied, where G6PD is the only NADPH source. The glutathione (GSH) redox status was measured both in vivo and after an in vitro oxidative challenge in pregnant women with gestational hypertension (n ϭ 19) vs. normotensive pregnant subjects (n ϭ 18) and controls (n ϭ 20). An erythrocyte GSH depletion with an increase in the oxidized form (GSSG) resulted in an elevated ratio GSSG/GSH (0.305 Ϯ 0.057; mean Ϯ SD) in hypertensive pregnant women vs. normotensive pregnant or control subjects (0.154 Ϯ 0.025; 0.168 Ϯ 0.073; p Ͻ .001). In hypertensive pregnant patients, a "GSH stability" decrease after an in vitro oxidative challenge suggested a reduced GSH recycling capacity resulting from an insufficient NADPH supply. The erythrocyte GSSG/GSH ratio may serve as an early and sensitive parameter of the oxidative imbalance and a relevant target for future clinical trials to control the effects of antioxidant treatment in women at increased risk of the pre-eclampsia syndrome.

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“…P reeclampsia (PE) is a potentially severe complication of pregnancy affecting 2-4% of pregnancies (1,2). The condition frequently necessitates preterm delivery for both maternal and fetal reasons (3).…”

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confidence: 99%

Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

2011

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INTRODUCTION:To better understand whether preeclampsia (Pe) increases the risk of bronchopulmonary dysplasia (BPD). RESULTS: Of 753 infants alive at 36 wks, 138 (18.3%) were exposed to Pe. BPD was not significantly related to exposure to Pe either before (odds ratio (OR) 0.73; 95% confidence interval (cI) 0.50, 1.06) or after adjustment for confounding variables (adjusted OR 1.14; 95% cI 0.71, 1.81). If infants were selected by gestational age alone, there was no association (OR 1.05; 95% cI 0.63, 1.75). In contrast, selecting by birth weight alone, Pe was associated with a significant reduction in BPD (OR 0.61, 95% cI 0.41, 0.91). however, this effect disappeared after adjustment for confounding variables. DISCUSSION: conclusions were unchanged when data from other studies were included in a pooled analysis. Pe does not significantly affect the risk of BPD in extremely preterm (eP) or extremely-low-birth-weight (eLBW) subjects. METHODS:We examined data on eP (<28 wks gestation) or eLBW (<1,000 g) infants live born in Victoria, australia, in three eras: 1991Victoria, australia, in three eras: -1992Victoria, australia, in three eras: , 1997Victoria, australia, in three eras: , and 2005. We compared the incidence of BPD (oxygen requirement at 36 wks' postmenstrual age) in the Pe group (infants exposed to Pe) with that in the remainder (nonexposed infants). We also contrasted results with comparable reported studies.

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Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications

Cited by 521 publications

References 41 publications

High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR

High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR

Blood glutathione redox status in gestational hypertension

Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants

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