Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure–dependent renal damage
Kentaro Kohagura,
Ryo Zamami,
Nanako Oshiro
et al.
Abstract:Hypertension, aging, and other factors are associated with arteriosclerosis and arteriolosclerosis, primary morphological features of nephrosclerosis. Although such pathological changes are not invariably linked with renal decline but are prevalent across chronic kidney disease (CKD), understanding kidney damage progression is more pragmatic than precisely diagnosing nephrosclerosis itself. Hyalinosis and medial thickening of the afferent arteriole, along with intimal thickening of small arteries, can disrupt … Show more
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