2008
DOI: 10.1093/brain/awn265
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Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

Abstract: White matter hyperintensities (WMH) are frequently seen on T(2)-weighted MRI scans of elderly subjects with and without Alzheimer's disease. WMH are only weakly and inconsistently associated with cognitive decline, which may be explained by heterogeneity of the underlying neuropathological substrates. The use of quantitative MRI could increase specificity for these neuropathological changes. We assessed whether post-mortem quantitative MRI is able to reflect differences in neuropathological correlates of WMH i… Show more

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Cited by 254 publications
(179 citation statements)
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“…There is a growing body of evidence suggesting that active white matter degeneration underlies amnestic mild cognitive impairment (Rowley et al, 2013, Chen et al, 2009Gouw et al, 2008;Duan et al, 2006;Liu et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…There is a growing body of evidence suggesting that active white matter degeneration underlies amnestic mild cognitive impairment (Rowley et al, 2013, Chen et al, 2009Gouw et al, 2008;Duan et al, 2006;Liu et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Only 3 of the studies excluded subjects with significant cerebrovascular disease in spite of the fact that there is probably a relationship between microglial activation and vascular microangiopathy in AD. In fact, combined neuropathological and postmortem MRI studies have shown that AD subjects with white matter hyperintensities had much greater microglial activation than controls [135,136]. These findings indicate that there is a potential link between microglial activation and vascular microangiopathy during the course of AD.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, some recent reports have shown that neuroinflammation may be involved [37,129,130,131]. Postmortem studies of AD brains demonstrated the presence of acute-phase inflammatory reactions in senile plaques and neurofibrillary tangles and their implication in neuronal death [132,133,134,135].…”
Section: Discussion and Future Directions For Studymentioning
confidence: 99%