Heterogeneity of p53 gene and k-ras gene in colorectal carcinoma

Kuwabara, Akifumi; Ajioka, Yoichi; Watanabe, Hidenobu; Hatakeyama, Katsuyoshi

doi:10.1016/s0016-5085(00)82263-5

Cited by 10 publications

(14 citation statements)

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“…Table 1 shows characteristics of the 6 oncology CPGs. [23][24][25][26][27][28] We identified and included all the CPG authors. We collected information about their medical specialties, affiliations, and positions at their affiliations by reviewing the CPGs or the webpage of the authors' affiliations.…”

Section: Study Populationmentioning

confidence: 99%

Evaluation of Pharmaceutical Company Payments and Conflict of Interest Disclosures Among Oncology Clinical Practice Guideline Authors in Japan

et al. 2019

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Section: Study Populationmentioning

confidence: 99%

Evaluation of Pharmaceutical Company Payments and Conflict of Interest Disclosures Among Oncology Clinical Practice Guideline Authors in Japan

et al. 2019

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“…31 The pioneering study from Griffith describing the SF supplied by the left colic artery (89%) and middle colic artery (11%) 3 was confirmed by 2 recent investigations using indocyanine green fluorescence and laparoscopic scintigraphic mapping. 32 The experts recommended to follow the complete mesocolic excision (CME) oncologic principles with ligation of the middle colic artery at its origin, as described by Dr Hohenberger 22 and in the Japanese guidelines 23 for the management of SF carcinoma. However, they also recommended in this Delphi consensus to ligate both the left colic artery and left branch of the middle colic artery for radical lymphadenectomy.…”

Section: Discussionmentioning

confidence: 99%

“…a Lymphadenectomy that includes central lymph nodes at the origin of the feeding artery (ie, root of the middle colic artery or IMA) 83% --Do you believe that the route of lymph node metastasis is different between splenic flexure carcinoma, distal transverse colon cancer close to the splenic flexure, and proximal descending colon cancer close to the splenic flexure, so the way of lymphadenectomy should be different between the 3 locations? Yes 39% 33% 26% No 55% 64% 74% Do you follow the central vascular ligation principles as described by Dr Hohenberger 22 or Japanese guidelines 23 Copyright © The American Society of Colon & Rectal Surgeons, Inc. Unauthorized reproduction of this article is prohibited.…”

Section: Delphi Statement First Round Second Round Third Roundmentioning

confidence: 99%

Standardization of the Definition and Surgical Management of Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?

Benlice

Parvaiz

Baca

et al. 2023

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Surgical management of splenic flexure carcinoma remains controversial. OBJECTIVE: This study aimed to establish an expert international consensus on splenic flexure carcinoma management. DESIGN: A 3-round online-based Delphi study was conducted between September 2020 and April 2021. SETTING: The first round included 18 experts from 12 different countries. For the second and third rounds, each expert in the first round was asked to invite 2 more colorectal surgeons (n = 47). Out of 47 invited experts, 89% (n = 42) participated in the second and third rounds of the consensus. INTERVENTIONS: A total of 35 questions were created and sent via the online questionnaire tool. MAIN OUTCOME MEASURES: Levels of recommendation based on voting concordance were graded as follows: more than 75% agreement was defined as strong, between 50% and 75% as moderate, and below 50% as weak. RESULTS: There was moderate consensus on the definition of splenic flexure (55%) as 10 cm from either side where the distal transverse colon turns into the proximal descending colon. Also, experts recommended an abdominopelvic CT scan plus intraoperative exploration (moderate consensus, 72%) for tumor localization and cancer registry. Segmental colectomy was the preferred technique for the management of splenic flexure carcinoma in the elective setting (72%). Moderate consensus was achieved on the technique of complete mesocolic excision and central vascular ligation principles for splenic flexure carcinoma (74%). Only strong consensus was achieved on the surgical approach for minimally invasive surgery (88%). LIMITATIONS: Subjective decisions are based on individual expert clinical experience and not evidence based. CONCLUSIONS: This is the first internationally conducted Delphi consensus study regarding splenic flexure carcinoma. The definition of splenic flexure remains ambiguous. To more effectively compare oncologic outcomes among different cancer registries, guidelines need to be developed to standardize each domain and avoid arbitrary definitions. See Video Abstract at http://links.lww.com/DCR/C143. ESTANDARIZACIÓN DE LA DEFINICIÓN Y MANEJO QUIRÚRGICO DEL CARCINOMA DE ÁNGULO ESPLÉNICO ESTABLECIDO POR UN CONSENSO INTERNACIONAL DE EXPERTOS UTILIZANDO LA TÉCNICA DELPHI: ¿ESPACIO PARA MEJORAR? ANTECEDENTES: El tratamiento quirúrgico del cáncer de ángulo esplénico sigue siendo controvertido. OBJETIVO: Establecer un consenso internacional de expertos sobre el manejo del cáncer del ángulo esplénico. DISEÑO: Se condujo un estudio Delphi en línea de 3 rondas entre septiembre de 2020 y febrero de 2021. ESCENARIO: La primera ronda incluyó a 18 expertos de 12 países distintos. Para la segunda y tercera rondas, a cada experto de la primera ronda se le pidió que invitara a 2 cirujanos colorrectales más de su región (n = 47). De los 47 expertos invitados, el 89% (n = 42) participó en la segunda y tercera ronda del consenso. INTERVENCIONES: Se crearon y enviaron un total de 35 preguntas a través de la herramienta de cuestionari...

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“…Each primitive protocol can be represented by a tree where each node corresponds to a particular situation and transitions correspond to possible messages an agent can either receive or send, i.e., the various interaction alternatives. In AgenTalk [12], protocols inherit from one another. They are described as scripts containing the various steps of a possible sequence of interactions.…”

Section: Related Workmentioning

confidence: 99%

Domain engineering to ensure flexibility on interaction laws of multi-agent systems

et al. 2007

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Heterogeneity of p53 gene and k-ras gene in colorectal carcinoma

Cited by 10 publications

References 0 publications

Evaluation of Pharmaceutical Company Payments and Conflict of Interest Disclosures Among Oncology Clinical Practice Guideline Authors in Japan

Evaluation of Pharmaceutical Company Payments and Conflict of Interest Disclosures Among Oncology Clinical Practice Guideline Authors in Japan

Standardization of the Definition and Surgical Management of Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?

Domain engineering to ensure flexibility on interaction laws of multi-agent systems

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