Heterogeneity of Motilin-Immunoreactive Cells in the Duodenum and Pyloric Region of Several Avian Species.

Yamada, Junzo; Arita, Megumi; Kitamura, Nobuo; Yamashita, T; Yanaihara, Noboru; Richardson, K.C.

doi:10.1679/aohc.56.261

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…In the present study, however, they were detected in the pyloric gland region as well as in the whole length of the intestine. To date, the presence of motilin-IR cells in the pyloric gland region has been reported in some reptiles [2,40] and birds [39], but not in mammals. The distribution of motilin-IR cells in the large intestine has been reported only in the musk shrew [21] and lesser mouse deer [1].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Survey of the Gut Endocrine Cells in the Common Tree Shrew (Tupaia belangeri).

Yamada

Tauchi

Rerkamnuaychoke

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. Regional distribution and relative frequency of endocrine cells in the gastrointestinal tract of the common tree shrew (Tupaia belangeri) were studied immunohistochemically. Ten types of immunoreactive endocrine cells were localized in the gastric mucosa, i.e., chromogranin-, serotonin-, gastrin-, somatostatin-, bovine pancreatic polypeptide (BPP)-, enteroglucagon-, pancreatic glucagon-, peptide tyrosine tyrosine (PYY)-, motilin-, and substance P (SP)-immunoreactive (IR) cells. In the intestine, 13 types of immunoreactive cells were observed, i.e., chromogranin-, serotonin-, somatostatin-, gastrin-, BPP-, enteroglucagon-, PYY-, secretin-, cholecystokinin (CCK)-, gastric inhibitory peptide (GIP)-, motilin-, neurotensin-, and SP-IR cells. The regional distribution and relative frequency of the cell types varied along the gastrointestinal tract. Basically, the types, distribution, and relative frequency of the gut endocrine cells were similar to those reported in other mammalian species. However, some characteristic findings were noted in the present study: (1) the considerably large number of gastrin-IR cells in the pyloric region; (2) numerous serotonin-IR cells in the stomach; (3) appreciable number of BPP-IR cells in the transitional region of the stomach; and (4) wide distribution of PYY-and motilin-IR cells in the gut.-KEY WORDS: gut endocrine cell, immunohistochemistry, intestine, stomach, tree shrew.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Survey of the Gut Endocrine Cells in the Common Tree Shrew (Tupaia belangeri).

Yamada

Tauchi

Rerkamnuaychoke

et al. 1999

The Journal of Veterinary Medical Science

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“…The DNES cells, which are endocrine cells that secrete hormones, undertake the important function in this absorption and regulation of digestion (SimSek et al, 2011). The morphology of the digestive organs and the distributions of enteroendocrine cells in the gastrointestinal mucosa have been shown to differ depending on the species and organs (Yamada et al, 1993;Mendes et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

A Histochemical and Immunohistochemical Study on the Gastrointestinal Tract of Sparrowhawk (Accipiter nisus)

Kara

Balkaya

2022

Int. J. Morphol.

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In the present study, we aimed to determine the localization and distribution of entero-endocrine cells in the gastrointestinal tract by immunohistochemical methods and understand the structure of the glycoproteins elaborated by the epithelium the digestive tract regions by histochemical methods. The nine sparrowhawks were euthanized, and gastrointestinal tract tissues were removed and fixed in formalin. The gastrointestinal tract sections were stained with immunohistochemical and histochemical techniques to evaluate the enteroendocrine cells and histomorphometric analysis. The results showed that the numbers of somatostatin in the ventriculus, gastrin in the proventriculus, serotonin in the duodenum and jejunum immunopositivity are higher, remaining segments of the gastrointestinal tract are detected slight positivity in the glucagon, gastrin, serotonin, and somatostatin. In conclusion, some endocrine cells localization and distribution and histomorphometry, and goblet cell counts were revealed in the gastrointestinal tract of the sparrowhawks.

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“…Endogenous motilin is implicated in the induction of phase III activity of the migrating motor complex (MMC) in the stomach and small intestine of humans and dogs, because: (i) intravenously applied motilin initiates phase III‐like contractions in the stomach and duodenum; (ii) the appearance of phase III is accompanied by the plasma oscillation of motilin; and (iii) immunoneutralization of endogenous motilin by antimotilin serum disrupts the occurrence of phase III activity in the stomach 1 , 2 . Although many immunohistochemical studies have demonstrated a heterogeneous distribution of motilin‐like immunoreactive substance‐containing cells in the intestinal mucosa (duodenum, jejunum and ileum) of several avian species, including the chicken, 3 –5 the physiological role of this peptide has not been clearly elucidated. In previous studies, it has been demonstrated that Leu 13 ‐porcine motilin and chicken motilin (ch‐MT) contract the chicken GI smooth muscle with different degrees of region‐dependent responsiveness and that motilin receptors present in the chicken are different from those in mammals 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Potentiation of motilin‐induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract

Kitazawa

Onodera

Taneike

2002

Neurogastroenterology Motil

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The present experiments were designed to determine whether or not endogenous nitric oxide (NO) modifies the contractile response to chicken motilin (ch-MT) in the gastrointestinal (GI) tract (proventriculus and small intestine) of the chicken. ch-MT (1 nmol L(-1)-1 micromol L(-1)) caused contractions of longitudinal muscle strips of the proventriculus through both myogenic and neurogenic (mostly cholinergic) mechanisms. On the other hand, ch-MT (0.1 nmol L(-1)-100 nmol L(-1)) contracted the small intestine (duodenum, jejunum and ileum) only through a myogenic mechanism. L-Nitroarginine methylester (L-NAME) potentiated, and L-arginine inhibited, the ch-MT- induced contraction without affecting the responsiveness of acetylcholine (ACh) or 5-hydroxytryptamine in the proventriculus. Electrical field stimulation (EFS)- and 1,1-dimethyl-4-phenylpiperazinium (DMPP)- induced contractions were also potentiated by L-NAME. The potentiation by L-NAME was prevented by L-arginine but not by D-arginine. However, in the presence of atropine or tetrodotoxin, neither L-NAME nor L-arginine modified the responses to ch-MT and DMPP. In contrast to the proventriculus, L-NAME and L-arginine were both ineffective in modifying the ch-MT-induced contraction in the small intestine. These results indicate that NO synthase inhibition potentiates the contractile response of ch-MT, EFS and DMPP in the chicken proventriculus through reduction of endogenous NO-mediated presynaptic inhibition on neural ACh release. However, NOS inhibition did not modify the myogenic (direct) action of ch-MT in gastric and intestinal smooth muscles of the chicken.

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Heterogeneity of Motilin-Immunoreactive Cells in the Duodenum and Pyloric Region of Several Avian Species.

Cited by 7 publications

References 19 publications

Immunohistochemical Survey of the Gut Endocrine Cells in the Common Tree Shrew (Tupaia belangeri).

Immunohistochemical Survey of the Gut Endocrine Cells in the Common Tree Shrew (Tupaia belangeri).

A Histochemical and Immunohistochemical Study on the Gastrointestinal Tract of Sparrowhawk (Accipiter nisus)

Potentiation of motilin‐induced contraction by nitric oxide synthase inhibition in the isolated chicken gastrointestinal tract

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