Heterogeneity of Mononuclear Phagocytes

Differentiation of C2D Macrophage Cells after Adoptive Transfer

“…Macrophages are known to play a key role in initiating acute inflammatory responses (27,41). A T-cell cytokine, IFN-␥, has been shown to have profound effects on macrophage function (66), including the induction of macrophage activation (2, 52, 61), increased microbicidal activity (2,48), and increased surface expression of MHC-II (41,66).…”

“…A T-cell cytokine, IFN-␥, has been shown to have profound effects on macrophage function (66), including the induction of macrophage activation (2, 52, 61), increased microbicidal activity (2,48), and increased surface expression of MHC-II (41,66). We therefore hypothesized that upon stimulation with IFN-␥, C2D macrophage cells would further alter their phenotype in vivo but would experience minimal effects in vitro.…”

Premature Ovarian Failure and Ovarian Autoimmunity

“…Macrophages also play a role in wound healing (124,125) and in the regulation of hemo-and lymphopoiesis (126,127). Histologically classic macrophages are large cells that show lamellapodia and vacuoles and possess an irregular, indented nucleus (128). They stain for nonspecific esterase and acid phosphatase throughout the cytoplasm.…”

“…A separate precursor in the bone marrow may exist for some subpopulations of macrophages (128). The monoblast and promonocyte remain in the bone marrow very briefly before entering the blood stream as monocytes (129).…”

Characterisation of Kupffer cells in some Amphibia

“…Finally, it is known that mammalian macrophages are generally formed of heterogeneous populations, mainly distinguishable on the basis of morphological, histochemical and functional criteria (Witsell & Schook, 1991 ;Armbrust & Ramadori, 1996 ; for reviews, see Ginsel, 1993 ;Leenen & Campbell, 1993). Also, in our amphibian specimens, we believe we can affirm that 2 KC populations are present in the liver, one made up of small cells anchored to the sinusoid walls which contain a few or no melanosomes, the other comprised of large cells, apparently more differentiated, and filled with numerous inclusion bodies, including a particularly large quantity of melanosomes.…”