Heterogeneity of mitochondrial creatine kinase

Kanemitsu, Fusae; Kageoka, Takeshi; Kira, Shohei

doi:10.1016/j.jchromb.2004.03.065

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…An alanine-9valine (Ala9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer {Kocabas, 2005 #51}. The heterogeneity of cardiac sarcomeric mitochondrial creatine kinase (creatine N-phosphotransferase, EC 2.7.3.2, sMi-CK), namely, brain ubiquitous Mi-CK (uMi-CK) and an atypical Mi-CK detected in the serum of a patient with ovarian cancer, was studied by Kanemitsu co-investigators [100] employing isoelectric focusing. These Mi-CKs were found to be slightly different from each other with respect to their pIs under the examined conditions.…”

Section: Mitochondria and Cancermentioning

confidence: 99%

Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer

Pourjafari¹,

Ghavami²,

Maddika³

2005

CMCAIAA

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This review focuses on the physiology of mitochondria as well as on the role of mitochondrial changes in cancer and in the immune system. After discussing the origin, structure, function and physiology of mitochondria, we focus on mitochondrial damage induced by antiviral and other drugs, reactive oxygen intermediates, physical tests like heat shock and ionizing radiation, hypoxia and hyperoxia. While discussing the effects of these noxious stimuli on mitochondria, we introduce terms such as "mitotoxicity" and "mitotoxins". Further parts of the review focus on the role of mitochondria in programmed cell death, and mitochondrial dysfunction observed in cancer. A significant portion of the review discusses the role of mitochondrial changes during the aging of the immune system, age-related changes of mitochondrial physiology, and mitochondrial proteins as auto-antigens. Using primary biliary cirrhosis as an example, we illustrate that the autoimmune condition is perpetuated by a pathologic immune response directed towards mitochondrial antigens. Finally we raise several questions, which we believe, need to be answered in order to improve the therapy of cancer autoimmunity and genetic diseases involving mitochondria.

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Section: Mitochondria and Cancermentioning

confidence: 99%

Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer

Pourjafari¹,

Ghavami²,

Maddika³

2005

CMCAIAA

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Laboratory and clinical features of abnormal macroenzymes found in human sera

Moriyama

Tamura

Nakano

et al. 2015

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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We report the analysis of unusual macroenzymes, performed in our laboratory, and review the relevant literature. In particular, we focused on macro AST, macroamylase, macro LD and macro CK. Macroenzymes are seen in healthy subjects, but can also be related to disease; thus, accurate detection is useful in day-to-day clinical practice. The macroenzyme is thought to be a specific antigen–antibody complex from the following findings: (1) the complex could be dissociated under acidic pH levels; (2) binding specificity of immunoglobulin in the complex was observed; (3) the binding site of immunoglobulin in the complex was Fab portion; and (4) the maternal IgG involved with macroenzyme was transferred to her children. This article is part of a Special Issue entitled: Medical Proteomics

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Heterogeneity of mitochondrial creatine kinase

Cited by 2 publications

References 43 publications

Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer

Mitochondrial Physiology and Toxicity (Mitotoxicity); Importance for the Immune System, Programmed Cell Death and Cancer

Laboratory and clinical features of abnormal macroenzymes found in human sera

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