Heterogeneity of Macrophage Populations and Expression of Galectin-3 in Cutaneous Wound Healing in Rats

Juniantito, Vetnizah; Izawa, Takeshi; Yamamoto, E.; Murai, Fumi; Kuwamura, Mitsuru; Yamate, Jyoji

doi:10.1016/j.jcpa.2011.01.012

Cited by 19 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because nonviable tissue was not decreased in this treatment despite the decrease in macrophage count, this may indicate that despite reducing macrophage numbers, the remaining cells are still highly active in the wound site. Considering the plasticity of macrophages involved in wound healing, significantly reducing the macrophages could have a negative effect on healing; the same macrophages needed to phagocytize debris are needed to initiate the repair processes . Further experiments on mechanisms of cell death will be needed to explore this concept.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of hyaluronic acid conjugation on anti‐TNF‐α inhibition of inflammation in burns

Friedrich

Sun

Natesan

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

Biomaterials capable of neutralizing specific cytokines could form the basis for treating a broad range of conditions characterized by intense, local inflammation. Severe burns, spanning partial- to full-thickness of the dermis, can result in complications due to acute inflammation that contributes to burn progression, and early mediation may be a key factor in rescuing thermally injured tissue from secondary necrosis in order to improve healing outcomes. In this work we examined the effects on burn progression and influence on the inflammatory microenvironment of topical application of anti-TNF-α alone, mixed with hyaluronic acid or conjugated to hyaluronic acid. We found that non-conjugated anti-TNF-α decreased macrophage infiltration to a greater extent than that conjugated to hyaluronic acid; however there was little effect on the degree of progression or IL-1β levels. A simple transport model is proposed to analyze the results, which predicts qualitative and quantitative differences between untreated burn sites and those treated with the conjugates. Our results indicate that conjugation of anti-TNF-α to high molecular weight hyaluronic acid provides sustained, local modulation of the post-injury inflammatory responses compared to direct administration of non-conjugated antibodies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Considering the plasticity of macrophages involved in wound healing, significantly reducing the macrophages could have a negative effect on healing; the same macrophages needed to phagocytize debris are needed to initiate the repair processes. 36,37 Further experiments on mechanisms of cell death will be needed to explore this concept.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyaluronic acid conjugation on anti‐TNF‐α inhibition of inflammation in burns

Friedrich

Sun

Natesan

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…At present little is known about the role of CD163 and TWEAK in the pathogenesis of fibrosis and the available evidence appears controversial. On one hand, CD163 positive macrophages, which are involved in wound healing, have been shown to exert profibrotic function [43]. Moreover, in the study by Yanaba et al ., serum concentration of sTWEAK inversely correlated with the risk of ILD, indicating that TWEAK might have a protective role against the development of fibrosis in SSc patients [25].…”

Section: Discussionmentioning

confidence: 99%

High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis

et al. 2013

View full text Add to dashboard Cite

IntroductionSystemic sclerosis (SSc) is an autoimmune disease characterized by chronic inflammation, vascular injury and excessive fibrosis. CD163 is a scavenger receptor which affects inflammatory response and may contribute to connective tissue remodelling. It has recently been demonstrated that CD163 can bind and neutralize the TNF-like weak inducer of apoptosis (TWEAK), a multifunctional cytokine which regulates inflammation, angiogenesis and tissue remodelling. We aimed to investigate the relationships between serum levels of soluble CD163 (sCD163) and soluble TWEAK (sTWEAK) in relation to disease manifestations in SSc patients.MethodsThis study included 89 patients with SSc who had not received immunosuppressive drugs or steroids for at least 6 months and 48 age- and sex-matched healthy controls (HC) from four European centres. Serum concentrations of sTWEAK and sCD163 were measured using commercially available ELISA kits.ResultsThe mean serum concentrations of sTWEAK were comparable between SSc patients (mean +/- SD: 270 +/- 171 pg/mL) and HC (294 +/- 147pg/mL, P >0.05). Concentration of sCD163 and sCD163/sTWEAK ratio were significantly greater in SSc patients (984 +/- 420 ng/mL and 4837 +/- 3103, respectively) as compared to HC (823 +/- 331 ng/mL and 3115 +/- 1346 respectively, P <0.05 for both). High sCD163 levels and a high sCD163/sTWEAK ratio (defined as > mean +2SD of HC) were both associated with a lower risk of digital ulcers in SSc patients (OR, 95%CI: 0.09; 0.01, 0.71, and 0.17; 0.06, 0.51, respectively). Accordingly, patients without digital ulcers had a significantly higher sCD163 concentration and sCD163/sTWEAK ratio as compared to SSc patients with digital ulcers (P <0.01 for both) and HC (P <0.05 for both). A high sCD163/sTWEAK ratio, but not high sCD163 levels, was associated with greater skin involvement.ConclusionsThe results of our study indicate that CD163-TWEAK interactions might play a role in the pathogenesis of SSc and that CD163 may protect against the development of digital ulcers in SSc. Further studies are required to reveal whether targeting of the CD163-TWEAK pathway might be a potential strategy for treating vascular disease and/or skin fibrosis in SSc.

show abstract

“…Recent scientific opinion, drawing mainly from murine models, generally agrees that macrophages possess dynamic plasticity that influence the entire wound healing process, displaying different phenotypes with different functions and capacities that are associated with both classical and alternative activation and change during the healing process . Impairment of the macrophage function can lead to delayed healing …”

Section: The Role Of Macrophages In Wound Healingmentioning

confidence: 99%

Macrophages: A review of their role in wound healing and their therapeutic use

Snyder

Lantis

Kirsner

et al. 2016

Wound Repair Regeneration

190

121

View full text Add to dashboard Cite

Macrophages are mononuclear phagocytes established during embryogenesis and derived from the yolk sac or the fetal liver but also recruited from the blood and bone marrow under proliferative inflammatory conditions (such as tissue repair). Most importantly, they take on distinct phenotypes and functions crucial to healing upon localization in the wound. The objective of this review is to summarize recent findings in regard to the cellular mechanisms of macrophages and chronic wounds. Advances in the potential use of macrophage therapy have arisen based, in part, on the fact that early recruitment of macrophages is critical to wound healing. Higher quality evidence is needed to support the use of macrophage therapy for chronic wound types, as is a better understanding of the signaling related to macrophage polarization, activation of macrophages, and their effect of mechanisms of repair. An evaluation of the currently available research on mechanism of action may lead to a better understanding of the signaling processes of the many macrophage phenotypes, as well as their roles and outcomes in wound healing, which could then guide the development and eventual widespread use of macrophage therapies.

show abstract

Heterogeneity of Macrophage Populations and Expression of Galectin-3 in Cutaneous Wound Healing in Rats

Cited by 19 publications

References 37 publications

Effects of hyaluronic acid conjugation on anti‐TNF‐α inhibition of inflammation in burns

Effects of hyaluronic acid conjugation on anti‐TNF‐α inhibition of inflammation in burns

High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis

Macrophages: A review of their role in wound healing and their therapeutic use

Contact Info

Product

Resources

About