Heterogeneity of Lymphocyte Homing Physiology: Several Mechanisms Operate in the Control of Migration to Lymphoid and Non‐Lymphoid Organs <i>In Vivo</i>

Pabst, Reinhard; Binns, R. M.

doi:10.1111/j.1600-065x.1989.tb00014.x

Cited by 151 publications

(68 citation statements)

References 51 publications

(44 reference statements)

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“…The lymphocyte content of the lung is similar to that of discrete PP in pigs, calves and lambs [58]. Like the intestinal immune system, the respiratory tract immune system includes lymphocytes in interstitial compartments and draining lymph nodes, as well as some intraepithelial cells.…”

Section: Respiratory Tractmentioning

confidence: 72%

“…No preferential migration of mesenteric lymph node blasts to the genital tract mucosa could be demonstrated for male rats [23], and the same seems to apply to the female genital tract [58]. In humans, oral immunisation was not an efficient way to elicit genital antibody responses, whereas rectal or nasal immunisation was more promising [82].…”

Section: Uterusmentioning

confidence: 92%

“…After injecting labelled blood lymphocytes i.v. into pigs, about 10% of them can be detected in the lungs 30 min later [58], most of them in the intravascular pool. After instillation into the bronchoalveolar space, labelled lymphocytes can be found in the interstitium and regional lymph nodes a few hours later [62].…”

Section: Respiratory Tractmentioning

confidence: 99%

“…the intestinal lamina propria, the intestinal epithelium, or to other peripheral lymph nodes. Additionally, some peripheral lymph node blasts also home to the gut [58]. However, it has been demonstrated that gut-derived lymphocytes preferentially migrate back to the GALT and to mesenteric lymph nodes [56].…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

“…In contrast, homing to PP or the spleen is rare. In young pigs, 1% of all labelled blood lymphocytes enter the tonsils -thus lymphocyte entry into the tonsils is relatively higher than entry into PP [58]. Additionally, migration of splenic or lymph node derived lymphocytes into the tonsils has been demonstrated.…”

Section: Tonsilsmentioning

confidence: 99%

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Lymphocyte migration studies

Bimczok

Rothkötter

2006

Vet. Res.

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-For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases -especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lymphocyte migration have been carried out in large animals, for example sheep, cattle and pigs. These species allow experimental procedures like in situ-organ labelling, lymphocyte retransfusion studies or lymph vessel cannulations. Such studies have made an important contribution to the understanding of the overall principles of lymphocyte migration especially in the mucosal immune system. Major results on the specific migration of naïve and memory T cells through lymphoid organs, the re-distribution of γ/δ T cells in the intestinal immune system and the emigration of newly produced B cells from the ileal Peyer's patches have been obtained in large animals. Since there are growing numbers of markers for large animals, and molecular biology methods are available in these species, experiments in large animals will be an essential tool for the understanding of lymphocyte migration especially in mucosal organs.

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Section: Respiratory Tractmentioning

confidence: 72%